Accepted for/Published in: JMIR Medical Informatics
Date Submitted: Aug 17, 2025
Open Peer Review Period: Sep 3, 2025 - Oct 29, 2025
Date Accepted: Mar 13, 2026
(closed for review but you can still tweet)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Clinical Note Generation from Doctor-Patient Conversations by Parameter-Efficient Fine-Tuning Large Language Models
ABSTRACT
Background:
Clinical note documentation is a vital yet time-intensive aspect of healthcare. While advancements in natural language processing (NLP) have transformed many domains, generating accurate summaries of doctor-patient conversations remains underexplored due to the limited availability of open-source datasets. Large Language Models (LLMs), with their training on vast datasets, present a promising solution to this challenge.
Objective:
Precision in clinical summarization is crucial as it directly impacts patient care and safety. This study evaluates the effectiveness of decoder-only LLMs compared to traditional encoder-decoder architectures in generating clinical notes from doctor-patient dialogues, focusing on maintaining medical accuracy and complying with healthcare privacy standards.
Methods:
We utilized the MTS-DIALOG dataset, containing 1,700 doctor-patient conversations paired with clinical notes. Our experiments involved fine-tuning several decoder-only LLMs, including Mistral, Meditron, and Llama, using a parameter-efficient fine-tuning approach.
Results:
Model performance was evaluated using ROUGE and BERT scores, demonstrating that Meditron-7B and Llama3-8B achieved state-of-the-art results, with Mistral-7B also performing competitively. The findings indicate that decoder-only LLMs, particularly Llama variants, outperform traditional models. Moreover, fine-tuning with higher quantization has the potential to further enhance performance.
Conclusions:
This study underscores the potential of decoder-only LLMs to transform clinical workflows by streamlining medical documentation, thereby enabling healthcare professionals to dedicate more time to patient care.
Citation
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Copyright
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