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Accepted for/Published in: JMIR Medical Informatics

Date Submitted: Aug 17, 2025
Open Peer Review Period: Sep 3, 2025 - Oct 29, 2025
Date Accepted: Mar 13, 2026
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Clinical Note Generation From Doctor-Patient Conversations Using Parameter-Efficient Fine-Tuning Large Language Models: Comparative Study

Ahmed S, Yousuf Sadeque F

Clinical Note Generation From Doctor-Patient Conversations Using Parameter-Efficient Fine-Tuning Large Language Models: Comparative Study

JMIR Med Inform 2026;14:e82545

DOI: 10.2196/82545

PMID: 42234930

Clinical Note Generation from Doctor-Patient Conversations Using Parameter-Efficient Fine-Tuning Large Language Models: Comparative Study

  • Saib Ahmed; 
  • Farig Yousuf Sadeque

ABSTRACT

Background:

Clinical note documentation is a vital yet time-intensive aspect of healthcare. While advancements in natural language processing (NLP) have transformed many domains, generating accurate summaries of doctor-patient conversations remains underexplored due to the limited availability of open-source datasets. Large Language Models (LLMs), with their training on vast datasets, present a promising solution to this challenge.

Objective:

Precision in clinical summarization is crucial as it directly impacts patient care and safety. This study evaluates the effectiveness of decoder-only LLMs compared to traditional encoder-decoder architectures in generating clinical notes from doctor-patient dialogues, focusing on maintaining medical accuracy and complying with healthcare privacy standards.

Methods:

We utilized the MTS-DIALOG dataset, containing 1,700 doctor-patient conversations paired with clinical notes. Our experiments involved fine-tuning several decoder-only LLMs, including Mistral, Meditron, and Llama, using a parameter-efficient fine-tuning approach.

Results:

Model performance was evaluated using ROUGE and BERT scores, demonstrating that Meditron-7B and Llama3-8B achieved state-of-the-art results, with Mistral-7B also performing competitively. The findings indicate that decoder-only LLMs, particularly Llama variants, outperform traditional models. Moreover, fine-tuning with higher quantization has the potential to further enhance performance.

Conclusions:

This study underscores the potential of decoder-only LLMs to transform clinical workflows by streamlining medical documentation, thereby enabling healthcare professionals to dedicate more time to patient care.


 Citation

Please cite as:

Ahmed S, Yousuf Sadeque F

Clinical Note Generation From Doctor-Patient Conversations Using Parameter-Efficient Fine-Tuning Large Language Models: Comparative Study

JMIR Med Inform 2026;14:e82545

DOI: 10.2196/82545

PMID: 42234930

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