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Accepted for/Published in: JMIR Research Protocols

Date Submitted: Feb 21, 2025
Open Peer Review Period: Feb 24, 2025 - Apr 21, 2025
Date Accepted: Apr 10, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Design of the Middle East African Registry for Women’s Cardiovascular Diseases: Protocol for a Multicenter Observational Study

Charfeddine S, Abid L, Chenik S, Ghrab A, Haddar O, Ben Krayen I, Boudiche S, Touati H, Ayedi O, Ammar MA, Ben Halima M, Ben Ayed H, Brahim A, ElAyech F, Thabet H, Mahfoudhi H, Jabloun TY, Ayadi Y, Ayadi A, Romdhani G, Gargouri H, Zidi O, Guedri MA, Tlili R, Trabelsi B, Hammami S, Othmen R, Antit S, Saidane S, Dardour S, Iddir S, Kharrat E, Cheikhrouhou A, Derwich M, Mrabet A, Lassoued T, Rekik E, Gmiha S, Laribi N, Lamine H, Triki Z, Ayari S, Boujelbene F, Boughzela E, Rekik H, Ben Ameur I, Abid S, Oueghlani K, Haggui A, Ben Halima A, Ouechtati W, Bennour E, Hammami R, Jabeur M, Zairi I, Drissa M, Addad F, Milouchi S, Mourali MS, Ben Slima H, Bezdah L, Neffati E, Ben Ameur Y, Kraiem S, Kachboura S, Kammoun I, Zakhama L, lbn Hadj Amor H, Ben Hamda K, Messoudi Y, Ben Hlima N, Dahmani R, Gamra H, Ibn Elhadj Z, Denguir H, Ghorbel C, Mechri N, Ernez Hajri S, Mebazaa A, Ben Dhaou F, Trigui M, Fehri W, Abdessalem S

Design of the Middle East African Registry for Women’s Cardiovascular Diseases: Protocol for a Multicenter Observational Study

JMIR Res Protoc 2026;15:e72944

DOI: 10.2196/72944

PMID: 42531435

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Design of The Middle East African Registry for Women's CardioVascular Disease (MEA-WCVD)

  • Salma Charfeddine; 
  • Leila Abid; 
  • Sarra Chenik; 
  • Aymen Ghrab; 
  • Oussama Haddar; 
  • Iheb Ben Krayen; 
  • Selim Boudiche; 
  • Haithem Touati; 
  • Oumaima Ayedi; 
  • Mohamed Amine Ammar; 
  • Manel Ben Halima; 
  • Houssem Ben Ayed; 
  • Asma Brahim; 
  • Faten ElAyech; 
  • Houssem Thabet; 
  • Houaida Mahfoudhi; 
  • Taha Yessine Jabloun; 
  • Yasmine Ayadi; 
  • Alaeddine Ayadi; 
  • Ghassen Romdhani; 
  • Hassen Gargouri; 
  • Oumayma Zidi; 
  • Mohamed Ali Guedri; 
  • Rami Tlili; 
  • Bechir Trabelsi; 
  • Selim Hammami; 
  • Rim Othmen; 
  • Saoussen Antit; 
  • Syrine Saidane; 
  • Sirine Dardour; 
  • Skander Iddir; 
  • Elmahdi Kharrat; 
  • Anis Cheikhrouhou; 
  • Mohamed Derwich; 
  • Amal Mrabet; 
  • Taha Lassoued; 
  • Emna Rekik; 
  • Sahar Gmiha; 
  • Niez Laribi; 
  • Hakim Lamine; 
  • Zied Triki; 
  • Samir Ayari; 
  • Fatma Boujelbene; 
  • Essia Boughzela; 
  • Hajer Rekik; 
  • Ines Ben Ameur; 
  • Syrine Abid; 
  • Khalil Oueghlani; 
  • Abddayem Haggui; 
  • Afef Ben Halima; 
  • Wejdene Ouechtati; 
  • Emna Bennour; 
  • Rania Hammami; 
  • Mariem Jabeur; 
  • Ihsen Zairi; 
  • Mariem Drissa; 
  • Faouzi Addad; 
  • Sami Milouchi; 
  • Mohamed Sami Mourali; 
  • Hedi Ben Slima; 
  • Leila Bezdah; 
  • Elyes Neffati; 
  • Youssef Ben Ameur; 
  • Sondos Kraiem; 
  • Salem Kachboura; 
  • Ikram Kammoun; 
  • Lilia Zakhama; 
  • Hassen lbn Hadj Amor; 
  • Khaldoun Ben Hamda; 
  • Yosra Messoudi; 
  • Nejah Ben Hlima; 
  • Rana Dahmani; 
  • Habib Gamra; 
  • Zied Ibn Elhadj; 
  • Hichem Denguir; 
  • Chayma Ghorbel; 
  • Nizar Mechri; 
  • Samia Ernez Hajri; 
  • Alexandre Mebazaa; 
  • Fedi Ben Dhaou; 
  • Maroua Trigui; 
  • Wafa Fehri; 
  • Salem Abdessalem

ABSTRACT

Background:

The escalating incidence of cardiovascular disease (CVD) in the general population, particularly among women, has resulted in increased morbidity and mortality in the Middle East and African (MEA) Regions. Despite this concerning tendency, women remain significantly underrepresented in cardiovascular research, with no large-scale prospective multicenter trials reflecting national data published to date. To address this gap, we initiated the "Women CardioVascular Disease Middle East African Registry (MEA-WCVD)" to establish a comprehensive database on the contemporary epidemiological profile and management of Heart Failure (HF), Atrial fibrillation (AF), ischemic heart disease (IHD) and Valvular Heart disease (VHD) in women.

Objective:

This study aims to compare the management of cardiovascular diseases in women and men in a MEA countries sample, according to the current practice guidelines and encompass the identification of gender-based disparities, specifically examining healthcare insurance, income, and access to healthcare services.

Methods:

This prospective observational study involves a one-shot visit where patients diagnosed with HF, AF, IHD, or VHD provide informed consent, and their data are collected in a centralized certified database. The registry spans 75 days, with plans for an extended protocol to assess 1-year clinical outcomes.

Results:

The study's findings, expected at the conclusion, will include a comprehensive evaluation of the demographic profile and care management practices for the most prevalent cardiovascular diseases in women worldwide, aligned with current guidelines. The MEA-WCVD registry is anticipated to become the largest database for Middle East African patients monitored for HF, AF, IHD, and VHD.

Conclusions:

The MEA-WCVD registry will provide unique and necessary data on the management and outcomes of the most common CV diseases (AF, HF, IHD and VHD) while comparing standard care management in women to men in MEA regions. This study will yield the largest contemporary cohort of patients with cardiovascular diseases in MEA countries and would provide valuable answers about real-world cardio-vascular clinical epidemiology and management.


 Citation

Please cite as:

Charfeddine S, Abid L, Chenik S, Ghrab A, Haddar O, Ben Krayen I, Boudiche S, Touati H, Ayedi O, Ammar MA, Ben Halima M, Ben Ayed H, Brahim A, ElAyech F, Thabet H, Mahfoudhi H, Jabloun TY, Ayadi Y, Ayadi A, Romdhani G, Gargouri H, Zidi O, Guedri MA, Tlili R, Trabelsi B, Hammami S, Othmen R, Antit S, Saidane S, Dardour S, Iddir S, Kharrat E, Cheikhrouhou A, Derwich M, Mrabet A, Lassoued T, Rekik E, Gmiha S, Laribi N, Lamine H, Triki Z, Ayari S, Boujelbene F, Boughzela E, Rekik H, Ben Ameur I, Abid S, Oueghlani K, Haggui A, Ben Halima A, Ouechtati W, Bennour E, Hammami R, Jabeur M, Zairi I, Drissa M, Addad F, Milouchi S, Mourali MS, Ben Slima H, Bezdah L, Neffati E, Ben Ameur Y, Kraiem S, Kachboura S, Kammoun I, Zakhama L, lbn Hadj Amor H, Ben Hamda K, Messoudi Y, Ben Hlima N, Dahmani R, Gamra H, Ibn Elhadj Z, Denguir H, Ghorbel C, Mechri N, Ernez Hajri S, Mebazaa A, Ben Dhaou F, Trigui M, Fehri W, Abdessalem S

Design of the Middle East African Registry for Women’s Cardiovascular Diseases: Protocol for a Multicenter Observational Study

JMIR Res Protoc 2026;15:e72944

DOI: 10.2196/72944

PMID: 42531435

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