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Accepted for/Published in: JMIR Research Protocols

Date Submitted: Feb 21, 2025
Open Peer Review Period: Feb 24, 2025 - Apr 21, 2025
Date Accepted: Apr 10, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Design of the Middle East African Registry for Women’s Cardiovascular Diseases: Protocol for a Multicenter Observational Study

Charfeddine S, Abid L, Chenik S, Ghrab A, Haddar O, Ben Krayen I, Boudiche S, Touati H, Ayedi O, Ammar MA, Ben Halima M, Ben Ayed H, Brahim A, ElAyech F, Allouche E, Thabet H, Mahfoudhi H, Jabloun TY, Ayadi Y, Ayadi A, Romdhani G, Gargouri H, Zidi O, Guedri MA, Tlili R, Trabelsi B, Hammami S, Othmen R, Antit S, Saidane S, Dardour S, Iddir S, Kharrat E, Cheikhrouhou A, Derwich M, Mrabet A, Lassoued T, Rekik E, Gmiha S, Laribi N, Lamine H, Triki Z, Ayari S, Boujelbene F, Boughzela E, Rekik H, Ben Ameur I, Abid S, Oueghlani K, Haggui A, Ben Halima A, Ouechtati W, Bennour E, Hammami R, Jabeur M, Zairi I, Drissa M, Addad F, Milouchi S, Mourali MS, Ben Slima H, Bezdah L, Neffati E, Ben Ameur Y, Kraiem S, Kachboura S, Kammoun I, Zakhama L, lbn Hadj Amor H, Ben Hamda K, Messoudi Y, Ben Hlima N, Dahmani R, Gamra H, Ibn Elhadj Z, Denguir H, Ghorbel C, Mechri N, Ernez Hajri S, Mebazaa A, Ben Dhaou F, Trigui M, Fehri W, Abdessalem S

Design of the Middle East African Registry for Women’s Cardiovascular Diseases: Protocol for a Multicenter Observational Study

JMIR Res Protoc 2026;15:e72944

DOI: 10.2196/72944

PMID: 42531435

Design of the Middle East African Registry for Women's Cardiovascular Diseases (MEA-WCVD): Protocol for a Multicenter Observational Study

  • Salma Charfeddine; 
  • Leila Abid; 
  • Sarra Chenik; 
  • Aymen Ghrab; 
  • Oussama Haddar; 
  • Iheb Ben Krayen; 
  • Selim Boudiche; 
  • Haithem Touati; 
  • Oumaima Ayedi; 
  • Mohamed Amine Ammar; 
  • Manel Ben Halima; 
  • Houssem Ben Ayed; 
  • Asma Brahim; 
  • Faten ElAyech; 
  • Emna Allouche; 
  • Houssem Thabet; 
  • Houaida Mahfoudhi; 
  • Taha Yessine Jabloun; 
  • Yasmine Ayadi; 
  • Alaeddine Ayadi; 
  • Ghassen Romdhani; 
  • Hassen Gargouri; 
  • Oumayma Zidi; 
  • Mohamed Ali Guedri; 
  • Rami Tlili; 
  • Bechir Trabelsi; 
  • Selim Hammami; 
  • Rim Othmen; 
  • Saoussen Antit; 
  • Syrine Saidane; 
  • Sirine Dardour; 
  • Skander Iddir; 
  • Elmahdi Kharrat; 
  • Anis Cheikhrouhou; 
  • Mohamed Derwich; 
  • Amal Mrabet; 
  • Taha Lassoued; 
  • Emna Rekik; 
  • Sahar Gmiha; 
  • Niez Laribi; 
  • Hakim Lamine; 
  • Zied Triki; 
  • Samir Ayari; 
  • Fatma Boujelbene; 
  • Essia Boughzela; 
  • Hajer Rekik; 
  • Ines Ben Ameur; 
  • Syrine Abid; 
  • Khalil Oueghlani; 
  • Abddayem Haggui; 
  • Afef Ben Halima; 
  • Wejdene Ouechtati; 
  • Emna Bennour; 
  • Rania Hammami; 
  • Mariem Jabeur; 
  • Ihsen Zairi; 
  • Mariem Drissa; 
  • Faouzi Addad; 
  • Sami Milouchi; 
  • Mohamed Sami Mourali; 
  • Hedi Ben Slima; 
  • Leila Bezdah; 
  • Elyes Neffati; 
  • Youssef Ben Ameur; 
  • Sondos Kraiem; 
  • Salem Kachboura; 
  • Ikram Kammoun; 
  • Lilia Zakhama; 
  • Hassen lbn Hadj Amor; 
  • Khaldoun Ben Hamda; 
  • Yosra Messoudi; 
  • Nejah Ben Hlima; 
  • Rana Dahmani; 
  • Habib Gamra; 
  • Zied Ibn Elhadj; 
  • Hichem Denguir; 
  • Chayma Ghorbel; 
  • Nizar Mechri; 
  • Samia Ernez Hajri; 
  • Alexandre Mebazaa; 
  • Fedi Ben Dhaou; 
  • Maroua Trigui; 
  • Wafa Fehri; 
  • Salem Abdessalem

ABSTRACT

Background:

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in the Middle East and Africa (MEA), with a rising incidence particularly among women. Despite this, women remain significantly underrepresented in cardiovascular research, and no large-scale, multicenter prospective trials have been conducted to provide national data. To address this gap, we established the Women CardioVascular Disease Middle East African Registry (MEA-WCVD) to create a comprehensive database on the epidemiological profile and management of heart failure (HF), atrial fibrillation (AF), ischemic heart disease (IHD), and valvular heart disease (VHD) in women.

Objective:

The primary aim of this study is to compare the management of cardiovascular diseases in women and men across MEA countries in accordance with current practice guidelines. The study also seeks to identify gender-based disparities in healthcare insurance, income, and access to cardiovascular services.

Methods:

The MEA-WCVD is a prospective, observational registry involving a one-time patient visit. Patients diagnosed with HF, AF, IHD, or VHD provide informed consent, and their clinical, demographic, and management data are collected in a centralized, certified database. The registry spans an initial 75-day data collection period, with an extended follow-up protocol planned to assess 1-year clinical outcomes.

Results:

The MEA-WCVD study was funded in April 2023, and data collection began in May 2023. As of July 2023, 15,366 participants have been enrolled across 25 centers. A one-year follow-up is expected to be completed by July 2024. Data analysis is planned to commence in July 2024, with primary results anticipated for publication in March 2025. The study aims to establish the largest registry in the Middle East and Africa for HF, AF, IHD, and VHD, providing valuable insights into demographic trends, clinical management, and adherence to current guidelines

Conclusions:

The MEA-WCVD registry will provide essential real-world data on the management and outcomes of the most prevalent cardiovascular diseases (HF, AF, IHD, VHD) in MEA regions. By directly comparing standard care management between men and women, this study will highlight gender disparities and inform future strategies for equitable cardiovascular care. The registry is expected to contribute to the largest contemporary cohort of CVD patients in the region, advancing knowledge in cardiovascular epidemiology and clinical practice.


 Citation

Please cite as:

Charfeddine S, Abid L, Chenik S, Ghrab A, Haddar O, Ben Krayen I, Boudiche S, Touati H, Ayedi O, Ammar MA, Ben Halima M, Ben Ayed H, Brahim A, ElAyech F, Allouche E, Thabet H, Mahfoudhi H, Jabloun TY, Ayadi Y, Ayadi A, Romdhani G, Gargouri H, Zidi O, Guedri MA, Tlili R, Trabelsi B, Hammami S, Othmen R, Antit S, Saidane S, Dardour S, Iddir S, Kharrat E, Cheikhrouhou A, Derwich M, Mrabet A, Lassoued T, Rekik E, Gmiha S, Laribi N, Lamine H, Triki Z, Ayari S, Boujelbene F, Boughzela E, Rekik H, Ben Ameur I, Abid S, Oueghlani K, Haggui A, Ben Halima A, Ouechtati W, Bennour E, Hammami R, Jabeur M, Zairi I, Drissa M, Addad F, Milouchi S, Mourali MS, Ben Slima H, Bezdah L, Neffati E, Ben Ameur Y, Kraiem S, Kachboura S, Kammoun I, Zakhama L, lbn Hadj Amor H, Ben Hamda K, Messoudi Y, Ben Hlima N, Dahmani R, Gamra H, Ibn Elhadj Z, Denguir H, Ghorbel C, Mechri N, Ernez Hajri S, Mebazaa A, Ben Dhaou F, Trigui M, Fehri W, Abdessalem S

Design of the Middle East African Registry for Women’s Cardiovascular Diseases: Protocol for a Multicenter Observational Study

JMIR Res Protoc 2026;15:e72944

DOI: 10.2196/72944

PMID: 42531435

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