Currently submitted to: JMIRx Med
Date Submitted: Jan 25, 2025
Open Peer Review Period: Jan 28, 2025 - Mar 25, 2025
(currently open for review)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
The Rise of Antibiotic Resistance and Its Global Impact
ABSTRACT
Antimicrobial resistance (AMR) presents a significant challenge to global public health, as overuse and misuse of antibiotics have led to the emergence of resistant bacteria, making infections more difficult and expensive to treat. This article explores the rise of antibiotic resistance, its impact on treatment regimens, and case studies highlighting the emergence of resistant organisms like Klebsiella pneumoniae, Mycobacterium tuberculosis, and Enterococcus faecium. It examines the causes of AMR, including overprescription in healthcare, agricultural use of antibiotics, and inadequate infection control measures, alongside the economic and ecological implications. Recent advancements in research, such as new antibiotic development, bacteriophage therapy, and antimicrobial peptides, offer potential solutions, but the need for global collaboration and improved stewardship programs is crucial. The article stresses the importance of continued research, surveillance, and the development of alternative therapies to combat AMR and mitigate its widespread impact on both public health and the economy.
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Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.