JMIR Publications

ABSTRACT

Background:

Wearable monitoring devices of an electrocardiogram (ECG) are widely used. However, the date of an adhesive single-lead ECG patch (SEP) in the diagnosis and 24-hour burden assessment of premature ventricular complex (PVC) is limited.

Objective:

We validated the diagnostic yield of SEP (mobiCARE™ MC-100, Seers Technology) for PVC detection and evaluated the PVC burden variation monitored by SEP over a 3-day monitoring period.

Methods:

This is a prospective study of patients with documented PVC on a 12-lead ECG. Patients underwent simultaneous ECG monitoring by the Holter and SEP on the first day. On the subsequent second and third days, ECG monitoring by SEP was continued and completed 3-day extended monitoring. The diagnostic yield of SEP for PVC detection was evaluated by comparison with the results obtained from the first day of Holter monitoring. PVC burden monitored by SEP for three days was used to assess daily and 6-hour PVC burden variation. The number of patients additionally identified to reach PVC thresholds of 10%, 15%, and 20% on 3-day extended monitoring of SEP and clinical factors associated with the higher burden variation were explored.

Results:

Recruited data of 134 monitored patients (mean age, 54.6 years; male, 33.6%) were analyzed. The median daily PVC burden was 2.4 (0.2-10.9) % by the Holter and 3.3 (0.3-11.7) % for the 3-day monitoring of SEP. The daily PVC burden detected on the first day of SEP was in agreement with that of the Holter: the mean difference was -0.07%, with 95% limits of agreement (-1.44%, 1.30%). A higher PVC burden on the first day was correlated with a higher daily (R2=0.34) and 6-hour burden variation (R2=0.48). Three-day monitoring by SEP identified 12/42 (28.6%), 10/56 (17.9%), and 4/60 (6.7%) more patients reaching 10%, 15%, and 20% of daily PVC burden, respectively. Younger age was associated with an additional identification of clinically significant PVC burden during the extended monitoring period (P=.02).

Conclusions:

A SEP accurately detects PVC with a comparable diagnostic yield to the Holter. Performing a 3-day PVC monitoring with SEP, especially among younger patients, may offer a pragmatic alternative for identifying more individuals exceeding the clinically significant burden threshold.