Accepted for/Published in: JMIR Research Protocols
Date Submitted: Aug 9, 2022
Date Accepted: Mar 12, 2023
Date Submitted to PubMed: May 16, 2023
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Airway sequelae after mechanical ventilation for COVID-19: a scoping review protocol
ABSTRACT
Background:
Airway sequelae after exposure to mechanical ventilation are important causes of mortality and morbidity due to breathing, deglutition, and voice production problems. These conditions often represent a clinical challenge and introduce high costs of care. Current knowledge on airway sequelae in SARS-CoV-2 infection survivors exposed to mechanical ventilation is limited.
Objective:
This scoping review aims to describe current knowledge on the most frequently encountered laryngeal and/or tracheal sequelae in patients exposed to mechanical ventilation due to SARS-CoV-2 infection.
Methods:
Inclusion criteria: This review will consider studies of any design reporting airway sequelae encountered in patients of both sexes and all ages who survived after exposure to mechanical ventilation in the context of infection with the SARS-CoV-2. Studies describing patients exposed to invasive and non-invasive mechanical ventilation will be considered.
Methods:
An initial search of MEDLINE identified keywords and index terms. The second search of MEDLINE, Scopus, and Web of Science followed, and a preliminary list of 483 references was obtained. After selecting eligible publications for review based on titles and abstracts, their reference lists will be used to identify additional studies. Regardless of the language or the publication date, published studies will be reviewed, whereas unpublished studies and non-scientific literature will be excluded. Two researchers will screen, select, and extract the publications, and data will be presented in tables.
Results:
The literature search was performed in May 2022 in MEDLINE, Scopus, Web of Science, LILACS (Literatura Latino-Americana e do Caribe em Ciências da Saúde), the Cochrane Library, ScienceDirect, Google Scholar, and OpenGrey; a total of 214 results were retrieved. Completion of the review is expected in mid-late-2022.
Conclusions:
This scoping review will be the first to describe the information regarding the development of laryngotracheal sequelae after severe SARS-CoV-2 infection. The data gathered by this review may lead to an understanding of the grade of upper airway sequelae after the pandemic and the impact in the future following years and allow for the assessment of possible interventions according to findings. Clinical Trial: This protocol was registered in Open Science Framework Registries on May 16, 2022. It can be found using the following link osf.io/9gefp.
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Copyright
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