Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Apr 17, 2026
Date Accepted: Sep 30, 2026

The final, peer-reviewed published version of this preprint can be found here:

Early-Stage Co-Creation and Human-Centered Development of Digital Therapeutics for Cognitive Rehabilitation in Early Neurocognitive Disorders: Convergent Mixed Methods Study

Rossetto F, Borgnis F, Mangione C, Serenelli C, Isernia S, Baglio F

Early-Stage Co-Creation and Human-Centered Development of Digital Therapeutics for Cognitive Rehabilitation in Early Neurocognitive Disorders: Convergent Mixed Methods Study

J Med Internet Res 2026;28:e98625

DOI: 10.2196/98625

PMID: 42976341

Early-Stage Co-Creation and Human-Centered Development of Digital Therapeutics for Cognitive Rehabilitation in Early Neurocognitive Disorders: A Convergent Mixed-Methods Study

  • Federica Rossetto; 
  • Francesca Borgnis; 
  • Chiara Mangione; 
  • Claudia Serenelli; 
  • Sara Isernia; 
  • Francesca Baglio

ABSTRACT

Background:

Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI) represent critical windows for early neurocognitive intervention, although access to timely, personalized rehabilitation remains limited. Digital health technologies offer opportunities to deliver scalable and individualized cognitive care; however, their successful implementation depends on a deep understanding of users’ needs, expectations, and potential barriers.

Objective:

This study explores the lived experiences, perceptions, and challenges of individuals with SCD and MCI regarding cognitive rehabilitation, focusing on digital formats

Methods:

: The study is framed within a Human-Centered Design (HCD) perspective, aiming to inform the user-centered development of digital rehabilitation solutions. A mixed-methods approach was adopted to integrate qualitative and quantitative data. A semi-structured interview, developed through a targeted literature review, focused on four thematic domains: Neurocognitive Abilities, Network Support, User Experience and Engagement, and Digital Divide. The interview was administered to individuals with SCD or MCI. Quantitative measures included Cognitive Failures Questionnaire (CFQ), Montreal Cognitive Assessment, and an ad-hoc Technological Expertise questionnaire. Qualitative data were analyzed using Applied Thematic Analysis, including transcription, double-blind coding by two psychologists, theme identification, and peer review.

Results:

Twenty-three participants (16 females; age: 74.3 years) were included. Participants reported low-to-moderate perceived cognitive difficulties (CFQ: 22.4±9.48) and moderate technological familiarity. Qualitative findings revealed frequent difficulties in memory, attention, and language during everyday activities, alongside the use of compensatory strategies. Emotional vulnerability, social withdrawal, and feelings of being misunderstood also emerged. Despite concerns about technological barriers and reduced supervision, participants expressed openness toward home-based telerehabilitation, appreciating its flexibility, autonomy, and comfort when adequate support is available.

Conclusions:

These findings highlight that effective digital rehabilitation solutions must emerge from iterative, user-informed processes capable of addressing both functional and emotional dimensions of early cognitive decline. The present findings will inform the further development of engaging, inclusive, and adaptable digital rehabilitation tools.


 Citation

Please cite as:

Rossetto F, Borgnis F, Mangione C, Serenelli C, Isernia S, Baglio F

Early-Stage Co-Creation and Human-Centered Development of Digital Therapeutics for Cognitive Rehabilitation in Early Neurocognitive Disorders: Convergent Mixed Methods Study

J Med Internet Res 2026;28:e98625

DOI: 10.2196/98625

PMID: 42976341

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.