Currently submitted to: JMIR Preprints
Date Submitted: Mar 28, 2026
Open Peer Review Period: Mar 28, 2026 - Mar 13, 2027
(currently open for review)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Effects of Monascus purpureus-fermented Angelica gigas Nakai in preventing oxidative stress in an Sprague-Dawley rat model of carbon tetrachloride-induced acute hepatic injury
ABSTRACT
Background:
We conducted this experimental study to examine whether fermented Angelica gigas (FAG) is effective in preventing oxidative stress in an Sprague-Dawley (SD) rat model of carbon tetrachloride (CTC)-induced acute hepatic injury (AHI).
Methods:
Male SD rats (n=36) were used to establish an animal model of CTC-induced AHI was established. They were given an intraperitoneal injection of CTC and then divided into the 6 experimental groups: NC group (n=6, olive oil), NCDG group (n=6, olive oil with 5% [w/w] AG), NFCDG group (n=6, olive oil with 5% [w/w] FAG), CC group (n=6, CTC), CCDG group (n=6, CTC with 5% [w/w] AG) and CFCDG group (n=6, CTC with 5% [w/w] FAG). Then, we compared serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels, serum and hepatic lipid levels and hepatic levels of thiobarbituric acid-reactive-substances (TBARS) and glutathione.
Results:
Our results showed that the FAG was effective in significantly protecting the liver from CTC-induced hepatotoxicity and significantly inhibiting CTC-induced accumulation of lipid in the liver.
Conclusions:
In conclusion, our results indicate that the FAG might be effective in preventing the hepatic injury due to oxidative stress in an animal model of CTC-induced hepatotoxicity.
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