Accepted for/Published in: JMIR Serious Games
Date Submitted: Mar 3, 2026
Date Accepted: Oct 12, 2026
BioDecryptors, a Bioinformatics Escape Game for Undergraduate and Postgraduate Learners in Clinical Microbiology: Prospective Before-and-After Study
ABSTRACT
Background:
Playful approaches such as escape games represent an innovative strategy to enhance medical students’ motivation and engagement.
Objective:
We developed BioDecryptors, an educational Escape Game designed to introduce the principles and tools of bioinformatics applied to clinical microbiology.
Methods:
Fifty-five students (22 second-year medical undergraduates and 33 postgraduate trainees) participated in the activity, which was organized in two levels tailored to participant profiles. Evaluation included a pre- and post-knowledge test, a pre- and post-motivation questionnaire, and a final satisfaction survey.
Results:
Knowledge scores increased significantly after the activity (7.0 to 7.9; p < 0.001), with no difference in score improvement between undergraduate and postgraduate students. Baseline motivation was higher among postgraduates, particularly regarding curiosity and willingness to learn bioinformatics, but these differences disappeared after the activity, except for two items. Overall satisfaction was very high (mean 4.7/5), with the playful aspect being especially valued, and 98% of participants expressed interest in taking part in similar activities.
Conclusions:
In conclusion, this Escape Game significantly improved knowledge and enhanced student motivation while generating high satisfaction. It represents an innovative and adaptable teaching tool for introducing bioinformatics in clinical microbiology education
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