Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Feb 24, 2026
Date Accepted: Jul 6, 2026

The final, peer-reviewed published version of this preprint can be found here:

Partially Virtual vs In-Person Care in Cardiovascular Conditions—Time Trends, Patient Characteristics, and Medication Management: Cohort Study

Nielsen SK, Meddis A, Blanche PF, Hashiba M, Schou M, Kirk UB, Kayser L, Torp-Pedersen C, Nouhravesh N, Risom SS, Holt A, Lamberts MK

Partially Virtual vs In-Person Care in Cardiovascular Conditions—Time Trends, Patient Characteristics, and Medication Management: Cohort Study

J Med Internet Res 2026;28:e94061

DOI: 10.2196/94061

PMID: 42679096

Partially Virtual Versus In-person Care in Cardiovascular Conditions – Time-trends, Patient characteristics and Medication Management: A Cohort Study

  • Sebastian Kinnberg Nielsen; 
  • Alessandra Meddis; 
  • Paul Frédéric Blanche; 
  • Mads Hashiba; 
  • Morten Schou; 
  • Ulrik Bak Kirk; 
  • Lars Kayser; 
  • Christian Torp-Pedersen; 
  • Nina Nouhravesh; 
  • Signe Stelling Risom; 
  • Anders Holt; 
  • Morten Kjøbek Lamberts

ABSTRACT

Background:

Despite increasing initiatives to promote virtual care, there are limited data describing usage, characteristics or clinical outcomes.

Objective:

To examine the use of virtual care in the management of cardiovascular disease.

Methods:

We used nationwide Danish registries to identify all patients with a first-time diagnosis of atrial fibrillation (AF), heart failure (HF), pulmonary embolism (PE) or acute coronary syndrome (ACS) between 2019 and 2023. Patients were categorized as receiving virtual care if followed up at least once virtually or in-person care if seen solely in-person. We evaluated temporal changes in the use of virtual care, calculated the odds of receiving virtual care and the chance of initiating guideline-directed medical therapy (GDMT).

Results:

45 885 patients with AF, 28 829 with HF, 8 208 with PE, and 10 615 with ACS were followed up. Among these 27.2% (AF), 52.2% (HF), 43.2% (PE), and 37.7% (ACS) had virtual follow-up. The use of virtual follow-up increased during COVID 19 and remained high afterwards. In 2023,16.5%–29.8% of patients’ first follow-up visits were virtual depending on the condition. Patient-specific factors significantly associated with virtual care were: Patients living in cities, for patients with AF (odds ratio [OR], 1.29; 95% confidence interval [CI], 1.23–1.36), HF (OR ,1.39, 95% CI, 1.31–1.47), and PE (OR, 1.17, 95% CI, 1.05–1.30), but not for patients with ACS; and “high frailty”: AF (OR, 1.67, 95%, CI 1.51–1.84 and PE (OR 1.69, 95% CI, 1.38–2.06). Initiation of GDMT was similar across conditions, regardless of virtual or in-person care e.g. for patients with HF, 2.17% initiated sodium-glucose cotransporter-2 inhibitors following a virtual visit, versus 4.77% after an in-person visit (Risk difference, -2.60%, 95% CI, -3.06 to -2.15).

Conclusions:

A considerable proportion of patients (27.2–52.2%), with cardiovascular disease received virtual care. The odds of receiving virtual care varied significantly based on patient characteristics, particularly place of residence and frailty score. Finally, small differences were found in the initiation of new GDMT.


 Citation

Please cite as:

Nielsen SK, Meddis A, Blanche PF, Hashiba M, Schou M, Kirk UB, Kayser L, Torp-Pedersen C, Nouhravesh N, Risom SS, Holt A, Lamberts MK

Partially Virtual vs In-Person Care in Cardiovascular Conditions—Time Trends, Patient Characteristics, and Medication Management: Cohort Study

J Med Internet Res 2026;28:e94061

DOI: 10.2196/94061

PMID: 42679096

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.