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Currently submitted to: JMIR Formative Research

Date Submitted: Jan 6, 2026

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

The Effects of Biomedical Animations on Hypertension Knowledge and Self-care Behavior: Randomized Controlled Pilot Study

  • Maan Isabella Cajita; 
  • Ardith Doorenbos; 
  • Nathan Tintle; 
  • William Galanter; 
  • Mohan Zalake

ABSTRACT

Background:

Uncontrolled hypertension (HTN) is often driven by poor engagement in recommended self-care behaviors. Barriers include limited knowledge, misaligned beliefs, and low motivation. Video-based patient education can improve these factors and is scalable and low burden. However, prior HTN interventions have not used biomedical animation to visually explain how lifestyle behaviors increase blood pressure and lead to chronic complications.

Objective:

To evaluate the effects of a video-based intervention using biomedical animation (Healthflix) on HTN knowledge, beliefs, motivation, and self-care behaviors among adults with hypertension.

Methods:

In this randomized controlled pilot study, 50 adults with HTN were assigned to either the Healthflix intervention or a written HTN fact sheet. The intervention and surveys were delivered via REDCap at baseline, immediately post-intervention, and at a two-week follow-up. Outcomes included HTN knowledge, health beliefs, motivation, and self-care behaviors.

Results:

Participants were primarily female (62%), college-educated (86%), and had a mean age of 39.1 ± 10.3 years. Post-intervention, Healthflix participants demonstrated significantly higher HTN knowledge (β = 0.32, p = 0.048) and perceived severity (β = 1.68, p = 0.046) than controls. At two-week follow-up, perceived benefits were significantly higher in the Healthflix group (β = 4.76, p = 0.03). Although additional outcomes favored the Healthflix group, differences were not statistically significant.

Conclusions:

The Healthflix intervention shows promise for improving HTN knowledge and beliefs among adults with HTN. Video-based education incorporating biomedical animation may enhance understanding of complex health information and support HTN self-care, warranting further study in larger trials. Clinical Trial: Not applicable


 Citation

Please cite as:

Cajita MI, Doorenbos A, Tintle N, Galanter W, Zalake M

The Effects of Biomedical Animations on Hypertension Knowledge and Self-care Behavior: Randomized Controlled Pilot Study

JMIR Preprints. 06/01/2026:90956

DOI: 10.2196/preprints.90956

URL: https://preprints.jmir.org/preprint/90956

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