Currently accepted at: Journal of Medical Internet Research
Date Submitted: Nov 30, 2025
Open Peer Review Period: Dec 1, 2025 - Jan 26, 2026
Date Accepted: Mar 17, 2026
(closed for review but you can still tweet)
This paper has been accepted and is currently in production.
It will appear shortly on 10.2196/88717
The final accepted version (not copyedited yet) is in this tab.
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Randomized Trial Evaluating a Tailored eHealth Intervention for Symptom Management in Couples Managing Prostate Cancer During the COVID-19 Pandemic
ABSTRACT
Background:
This randomized controlled trial evaluated the efficacy of the “Prostate Cancer (PCa) Education & Resources for Couples” (PERC) eHealth intervention to improving the outcomes for patients and their partners.
Methods:
We enrolled 280 dyads (560 individuals) of patients with localized PCa who recently completed treatment, and their partners. Dyads were randomized to PERC or a control group who accessed an an NCI PCa website. Validated questionnaires assessed quality of life (QOL, FACT-G total; primary outcomes) and FACT-G subdomains, symptom and psychosocial measures (secondary outcomes) at baseline and 4, 8, and 12 months (T1-T4). Multilevel linear mixed models tested intervention effects.
Results:
FACT-G total, subdomain, and overall overall psychosocial outcomes did not differ significantly between groups over time. PERC patients reported marginally higher physical QOL (95% CI: –0.1 to 1.9, d=0.33), better illness appraisal (95% CI: 0.0 to 0.4, d=0.38), lower pain (95% CI: –5.3 to –0.2, d=0.38) at T4, and less frequent fatigue across time (95% CI: –3.9 to –0.4). PERC partners reported less urinary symptom bother at T3 (95% CI: -1.0 to14.1, d=0.44). Discussion: PERC demonstrated exploratory benefits including patients’ improved physical QOL, less fatigue, lower pain, improved illness appraisal in patients, and less urinary bother in partners.
Citation
Request queued. Please wait while the file is being generated. It may take some time.
Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.