Currently submitted to: JMIR Formative Research
Date Submitted: Nov 24, 2025
Open Peer Review Period: Dec 8, 2025 - Feb 2, 2026
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Insights from Year One of a Clinical Study Examining Uptake of a Blood-based Colorectal Cancer Screening Test in Medically Underserved Populations
ABSTRACT
Background:
Background:
About 30% of adults who are eligible for colorectal cancer (CRC) screening have never been screened. Adherence to CRC screening is particularly poor among medically underserved populations, including those with low income and racial/ethnic minority populations. Blood-based screening offers a less invasive alternative to stool-based tests and colonoscopy, potentially increasing adherence.
Objective:
This pre-defined interim analysis of a clinical study examines sociodemographic barriers and facilitators for implementing a trial using blood-based CRC screening, as well as patient satisfaction with the CRC screening blood test.
Methods:
Methods:
We partnered with two Federally Qualified Health Centers (FQHCs) in the Midwest to conduct the clinical study. Eligible participants were 45-75 years of age at average risk for CRC, and were never screened or not up to date with screening. Participants were identified from electronic health records (EHR) and were invited to participate in the study, including a post-study satisfaction survey.
Results:
Results:
From 482 eligible individuals, 198 expressed interest in participating in the study, and 79 were successfully enrolled. Although Hispanic/Latino individuals (OR: 2.51, 95% CI 1.35-4.66) were more likely to show interest in the blood-based test, there was a higher participation rate among Non-Hispanic White individuals (65%). Forty participants completed a satisfaction survey, and those who responded reported a positive experience with the blood test, indicating a high mean score (on a scale of 1-10) in terms of convenience (mean=9.25) and comfort (mean=9.23).
Conclusions:
Conclusion: Preliminary results from the first year of this study suggest that the blood-based screening option has a promising uptake among medically underserved populations with historically low adherence of CRC screening, such as racial/ethnic minorities. Clinical Trial: NCT05536713
Citation
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