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Lalama E, Csanalosi M, Kabisch S, Wilson-Barnes S, Gymnopoulos LP, Dimitropoulos K, Rouskas K, Anagnostis A, Oikonomidis I, Hadjileontiadis L, Cornelissen V, Hassapidou M, Pagkalos I, Balula Dias S, Hart K, Pfeiffer AH
Effect of a Personalized Mobile App on Glucose Control in Adults With Prediabetes and Type 2 Diabetes: Exploratory Pilot Randomized Controlled Trial
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Assessment of dietary advice delivered by a personalized mobile application to improve glucose control for adults with prediabetes and type 2 diabetes: Randomized Controlled Trial
Elena Lalama;
Marta Csanalosi;
Stefan Kabisch;
Saskia Wilson-Barnes;
Lazaros P. Gymnopoulos;
Kosmas Dimitropoulos;
Konstantinos Rouskas;
Argiriou Anagnostis;
Ioannis Oikonomidis;
Leontios Hadjileontiadis;
Veronique Cornelissen;
Maria Hassapidou;
Ioannis Pagkalos;
Sofia Balula Dias;
Kathryn Hart;
Andreas H. Pfeiffer
ABSTRACT
Background:
The incidence of type 2 diabetes (T2D) continues to increase, and the lack of individualized therapy strategies hinders patient engagement with and commitment to a healthy lifestyle. The PROTEIN project aimed to facilitate users to choose healthy living, thereby improving their metabolism and T2D management.
Objective:
To assess the efficacy of a personalized mobile application to achieve a 5% time in range (TIR) improvement over a 12-week intervention in adults with prediabetes or T2DM.
Methods:
We conducted a randomized controlled trial (RCT) with 21 individuals with T2D or prediabetes who used a continuous glucose monitoring (CGM) system and the PROTEIN mobile application (PROTEIN app) for personalized meals and exercise recommendations based on their glucose levels and physical activity.
Results:
The TIR of the participants increased (p<0.05; from 71.8% ± 27.3% to 76.0% ± 28.1%) with individual use of the PROTEIN app but did not achieve a 5% improvement overall. Glycated hemoglobin, fasting blood glucose, and body weight did not fluctuate throughout the 12-week intervention. The dropout rate was high and the average duration of use of the PROTEIN app was 42 days (range 5 to 84).
Conclusions:
Our results showed an improvement in TIR with the use of the PROTEIN-app. Integrating wearables and automated personalization for wellbeing is an innovative approach that must keep pace with the accelerated development of ever-evolving technologies. Clinical Trial: ClinicalTrials.gov: registration no. NCT05951140
https://clinicaltrials.gov/study/NCT05951140
Citation
Please cite as:
Lalama E, Csanalosi M, Kabisch S, Wilson-Barnes S, Gymnopoulos LP, Dimitropoulos K, Rouskas K, Anagnostis A, Oikonomidis I, Hadjileontiadis L, Cornelissen V, Hassapidou M, Pagkalos I, Balula Dias S, Hart K, Pfeiffer AH
Effect of a Personalized Mobile App on Glucose Control in Adults With Prediabetes and Type 2 Diabetes: Exploratory Pilot Randomized Controlled Trial