Accepted for/Published in: JMIR Pediatrics and Parenting
Date Submitted: Nov 9, 2025
Date Accepted: Mar 4, 2026
Dental health in pediatric patients with different types of mucopolysaccharidosis: a retrospective cross-sectional study
ABSTRACT
Background:
Patients with mucopolysaccharidosis (MPS) appear to have an increased risk of developing dental disease.
Objective:
This study aimed to evaluate the status of the dental caries and dental anomalies among Chinese patients with different types of MPS.
Methods:
This retrospective study included 102 pediatric MPS patients visited at the Capital Center for Children’s Health over the past 20 years. Dental caries and anomalies was assessed through clinical records and radiographic data.
Results:
Dental caries were observed in 55.9% (57/102), and no statistically significant difference was observed across the MPS subtypes (P = 0.723). The d4-6mft (deep dentinal lesions) contributed most to the total dmft score. The overall prevalence of dental anomalies was 32.4% (33/102), with a statistically significant difference among MPS subtypes (P = 0.005). Patients with MPS-IV had a significantly higher risk of dental anomalies compared to those with MPS-II (OR = 6.32, 95% CI: 1.55-28.28, P = 0.012), after adjusting for age and gender.
Conclusions:
The prevalence of dental anomalies differed significantly across MPS subtypes, while that of dental caries did not. These findings emphasize the need for early, targeted preventive care and tailored dental interventions to improve oral health outcomes in this population. Clinical Trial: The study was registered with the Chinese Clinical Trial Registry (ChiCTR2400090276).
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