Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: JMIR Aging

Date Submitted: Nov 9, 2025
Date Accepted: Mar 19, 2026

The final, peer-reviewed published version of this preprint can be found here:

Developing and Testing a Brief Mindfulness Just-in-Time Adaptive Intervention to Reduce Stress Among Caregivers of People With Dementia: Quasi-Experimental Study

Kor PPK, Tsang APL, Cheung DSK, Zarit SH, Xie H, Qian M, Tan KC, Zheng Y, Chu AMY, Chou KL

Developing and Testing a Brief Mindfulness Just-in-Time Adaptive Intervention to Reduce Stress Among Caregivers of People With Dementia: Quasi-Experimental Study

JMIR Aging 2026;9:e87316

DOI: 10.2196/87316

PMID: 42247635

Developing and testing a brief mindfulness just-in-time adaptive intervention to reduce stress among caregivers of people with dementia: A quasi-experimental study

  • Patrick Pui Kin Kor; 
  • Alex Pak Lik Tsang; 
  • Daphne Sze Ki Cheung; 
  • Steven H. Zarit; 
  • Haoran Xie; 
  • Min Qian; 
  • Kay Chen Tan; 
  • Yuanqing Zheng; 
  • Amanda Man Ying Chu; 
  • Kee Lee Chou

ABSTRACT

Background:

Dementia caregiving entails chronic, fluctuating stress with downstream risks to caregiver mental health and care quality. Mindfulness-based interventions can reduce caregiver stress; however, moment-to-moment fluctuations in stress may limit receptivity to practice at any given time. We developed a brief mindfulness just-in-time adaptive intervention (JITAI) that aims to deliver support at the right moment by using machine learning algorithms to optimize notification timing based on receptivity to engage in brief mindfulness practices.

Objective:

To evaluate the feasibility, acceptability, and effectiveness of a brief mindfulness JITAI for dementia caregivers on stress, depressive symptoms, caregiver burden, sleep, quality of life, and trait mindfulness.

Methods:

A single-arm, pre-test post-test design was adopted. 120 community-dwelling dementia caregivers were recruited to participate in the 18-day intervention, which included four days of psychoeducation delivered via videos and phone coaching, alongside an in-app brief, low-dose Mindfulness-based Stress Reduction (MBSR) component. From days 5 to 11, prompts were delivered either by a static machine learning model trained on prior pilot data or at random times, with equal probability. From days 12 to 18, three delivery models were used with equal probability: static, random, and an adaptive model that updated per participant using accumulating receptivity data. Feasibility and acceptability were assessed post-intervention; standardized measures of stress, depressive symptoms, caregiver burden, positive aspects of caregiving, sleep, quality of life, and trait mindfulness were collected via phone interviews at baseline and post-intervention.

Results:

Retention was 100%. Most participants (92.5%) found the app easy to use; 81.7% perceived it as helpful for stress management; and 80.0% would recommend it to other caregivers. Pre–post analyses indicated significant improvements in perceived stress (p < .001), depressive symptoms (p < .001), caregiver burden (p < .01), positive aspects of caregiving (p < .001), and subjective sleep quality (p < .05). Health-related quality of life and trait mindfulness did not change significantly.

Conclusions:

A brief, smartphone-delivered mindfulness JITAI for dementia caregivers was feasible and acceptable, with high retention and positive user evaluations. Pre–post findings suggest improvements in stress, depressive symptoms, caregiving burden, positive aspects of caregiving, and sleep, supporting the potential of adaptive, technology-enabled interventions to provide timely support to caregivers. Clinical Trial: Chinese Clinical Trial Registry (ChiCTR2300071361)


 Citation

Please cite as:

Kor PPK, Tsang APL, Cheung DSK, Zarit SH, Xie H, Qian M, Tan KC, Zheng Y, Chu AMY, Chou KL

Developing and Testing a Brief Mindfulness Just-in-Time Adaptive Intervention to Reduce Stress Among Caregivers of People With Dementia: Quasi-Experimental Study

JMIR Aging 2026;9:e87316

DOI: 10.2196/87316

PMID: 42247635

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.