JMIR Publications

ABSTRACT

Basal cell carcinoma (BCC) is the most common cutaneous malignancy, with multiple localized lesions typically linked to genodermatoses or environmental exposures. Rarely, non-syndrome BCCs (NSBCC) may be present in an agminated pattern without identifiable genetic or environmental risk factors. We present two patients, one with focal distribution of BCCs along the frontal scalp/hairline, and the other with unilateral distribution of BCCs on the right side of the face. We present two patients with numerous agminated basal cell carcinomas (BCCs) without syndromic features. Patient 1, a 67-year-old woman, developed 22 BCCs over 24 years, 19 localized to the frontal scalp. Patient 2, a 78-year-old man, developed 44 BCCs over 11 years, predominantly on the right face with history of adolescent full-face radiation, representing the highest number of non-syndromic agminated BCCs reported to date. We report two cases of non-syndromic agminated basal cell carcinomas treated with surgical and destructive modalities. Their strikingly focal distribution raises the possibility of localized genetic or environmental factors, highlighting the need for further studies to clarify the mechanisms underlying non-syndromic agminated BCC and determine whether it represents a distinct entity.