Currently submitted to: JMIR Formative Research
Date Submitted: Nov 20, 2025
(closed for review but you can still tweet)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Feasibility, Usability, and Acceptability of an Adaptive Mobile Health Medication Adherence Intervention for Youth: Iterative Mixed Methods Human-Centered Design Study
ABSTRACT
Background:
Adolescents and young adults with chronic health conditions often struggle to adhere to their daily oral medications. Transdiagnostic mobile health interventions have the potential to support medication adherence by reaching youth in their daily lives and at a large scale.
Objective:
The aim of this study was to partner with a Community Advisory Board to design an adaptive medication adherence mobile health intervention and assess the feasibility, usability, and acceptability of the intervention during iterative design cycles.
Methods:
Using human-centered design methods, researchers collaborated with a Community Advisory Board of young adult patients to design an intervention prototype, collect mixed methods feedback from (N = 22) 15-20 year old patients, and iteratively refine the intervention to optimize feasibility, usability, and acceptability.
Results:
The design process produced a moderately feasible, usable, and acceptable intervention. However, prospective acceptability (before trying the intervention) is still insufficient, and more refinement is needed to support users in learning to use the intervention, increase variety and interest during use, and dynamically adapt the intervention to the specific user over time.
Conclusions:
Partnering with community members early in the development of an intervention may improve the ultimate feasibility, usability, and acceptability of digital heath tools. Human-centered design offers a rapid, practical, creative framework for identifying what works and what needs to be improved early in the lifecycle of a new intervention. Clinical Trial: NCT05719064
Citation
