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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Oct 29, 2025
Open Peer Review Period: Oct 30, 2025 - Dec 25, 2025
Date Accepted: Feb 14, 2026
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Rheumatic Digital Twin: Proposed Machine Learning–Based Multimodal Framework to Inform Clinical Decision-Making

Selani D, Knevel R, Reinders M, van den Akker E

Rheumatic Digital Twin: Proposed Machine Learning–Based Multimodal Framework to Inform Clinical Decision-Making

J Med Internet Res 2026;28:e86763

DOI: 10.2196/86763

PMID: 42081548

Rheumatic Digital Twin: A Proposed Machine Learning-Based Multi-Modal Framework to Inform Clinical Decision-Making

  • Daniyal Selani; 
  • Rachel Knevel; 
  • Marcel Reinders; 
  • Erik van den Akker

ABSTRACT

Medical digital twins (MDTs) apply advanced machine learning algorithms on longitudinally collected data to transform patient care. We introduce an MDT framework designed for rheumatic diseases, integrating multi-modal data from electronic health records. By designing an architecture that can effectively represent each data modality, both at baseline and during treatment, we aim to construct comprehensive and informative digital twins that encapsulate a patient’s individual characteristics, clinical history, and current health status, thereby supporting the implementation of precision medicine.


 Citation

Please cite as:

Selani D, Knevel R, Reinders M, van den Akker E

Rheumatic Digital Twin: Proposed Machine Learning–Based Multimodal Framework to Inform Clinical Decision-Making

J Med Internet Res 2026;28:e86763

DOI: 10.2196/86763

PMID: 42081548

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