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Accepted for/Published in: JMIR Formative Research

Date Submitted: Oct 20, 2025
Date Accepted: Feb 13, 2026

The final, peer-reviewed published version of this preprint can be found here:

Development of the Healthy Women Intervention to Increase Women’s Engagement in Medication Treatment for Opioid Use Disorder: Mixed Methods, User-Centered Design Approach

Sugarman DE, Levine EA, Wang CL, Korte FM, Barbaro NA, Weiss RD, Marsch LA, Campbell AN, Greenfield SF

Development of the Healthy Women Intervention to Increase Women’s Engagement in Medication Treatment for Opioid Use Disorder: Mixed Methods, User-Centered Design Approach

JMIR Form Res 2026;10:e85195

DOI: 10.2196/85195

PMID: 41915447

Development of the Healthy Women Intervention to Increase Women’s Engagement in Medication Treatment for Opioid Use Disorder: A Mixed-Methods, User-Centered Design Approach

  • Dawn E. Sugarman; 
  • Emily A. Levine; 
  • Calle L. Wang; 
  • Francesca M. Korte; 
  • Nicole A. Barbaro; 
  • Roger D. Weiss; 
  • Lisa A. Marsch; 
  • Aimee N.C. Campbell; 
  • Shelly F. Greenfield

ABSTRACT

Background:

Rates of opioid use disorder (OUD) have increased among women over the past two decades. Medication treatment for opioid use disorder (MOUD) is effective but underutilized. Gender-specific treatments for women have been associated with improved substance use outcomes. However, these treatments have not specifically targeted women’s engagement in MOUD and the impact of existing gender-specific treatments is restricted by in-person delivery.

Objective:

The aim of this study was to develop a digital intervention to feasibly deliver gender-specific care that addresses the individualized needs of women with OUD to increase engagement in MOUD.

Methods:

A mixed-methods, user-centered design approach was used to inform the development of a digital intervention. In Phase 1, qualitative interviews were conducted with women with lived experience (WLE) of OUD (N=20) and providers who treat women with OUD (N=8). Interviews were recorded, transcribed, and coded for themes. In addition, a larger sample of treatment providers (N=55) completed an online survey to further inform the content of the digital intervention. Phase 2 consisted of designing, beta-testing (N=5), and refining the intervention.

Results:

The qualitative interview data from WLE and providers were categorized into three treatment-related themes (1) barriers to treatment, (2) facilitators to successful recovery, and (3) important issues to address in treatment, and three technology related themes (4) positives of using technology as part of treatment, (5) suggested technology features, and (6) barriers to using technology. Survey data provided additional information on barriers to treatment and suggested technology features. Based on these data and preliminary work, the Healthy Women intervention was created. Minor edits to content and visual design were made in the beta-testing phase. The final version includes a web-based component with 6 topic modules and a mobile component. Topics in the web-based component are presented through infographics, text, videos, and interactive questions. The mobile component includes daily motivational messages, skills practice activities (2/week), weekly check-ins, and resources (always available).

Conclusions:

Important themes and suggested features from women with lived experience and providers were incorporated into a digital intervention for women with OUD. Data on feasibility, satisfaction, and engagement with the Healthy Women intervention is currently being collected in Phase 3, a pilot randomized controlled trial.


 Citation

Please cite as:

Sugarman DE, Levine EA, Wang CL, Korte FM, Barbaro NA, Weiss RD, Marsch LA, Campbell AN, Greenfield SF

Development of the Healthy Women Intervention to Increase Women’s Engagement in Medication Treatment for Opioid Use Disorder: Mixed Methods, User-Centered Design Approach

JMIR Form Res 2026;10:e85195

DOI: 10.2196/85195

PMID: 41915447

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