Accepted for/Published in: JMIR Research Protocols
Date Submitted: Oct 17, 2025
Date Accepted: Feb 18, 2026
Date Submitted to PubMed: Apr 10, 2026
Identifying preferences for prostate cancer screening among American Indian men (Project AIMEPCCo): Protocol for a discrete choice experiment
ABSTRACT
Background:
American Indian (AI) men are disproportionately impacted by prostate cancer (PC) compared to men who identify as White and experience the worst PC outcomes of any racial/ethnic group. To address these disparities, it is important to better understand AI men’s preferences regarding PC screening.
Objective:
(1) Conduct a literature review, followed by qualitative, culturally responsive formative research with AI men, (2) develop and field a discrete choice experiment survey to elicit the preferences of AI men toward prostate cancer screening, and (3) identify feasible, culturally appropriate, preference-concordant screening strategies that are targeted for AI men.
Methods:
We will use discrete choice experiment (DCE) methodology to elicit the PC screening preferences among men from the Lumbee Tribe in North Carolina, one of the largest AI tribes in the eastern United States. We will use a systematic literature review, followed by rigorous, theoretically grounded qualitative work, to inform attribute selection, paying particular attention to cultural responsiveness. We will then pilot the DCE among Lumbee men to assess cultural responsiveness and comprehension of the choice tasks. We will collect preference data from 100 Lumbee men between the ages of 40 and 69. Choice data will be analyzed using mixed logit models; trade-offs will be described using marginal rates of substitution.
Results:
DCE data is expected to start being collected in September 2025.
Conclusions:
This will be the first study to use a culturally-responsive approach to DCE development in an indigenous population. The findings from this study can be used to educate providers regarding culturally-responsive PC screening and to inform the design of interventions to increase preference-concordant PC screening in AI men. Clinical Trial: This study has been pre-registered on the OpenScienceFramework (OSF) study protocol registry (osf.io/4gnr2).
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