Previously submitted to: JMIR Nursing (no longer under consideration since Apr 09, 2026)
Date Submitted: Sep 27, 2025
Open Peer Review Period: Sep 29, 2025 - Nov 24, 2025
(closed for review but you can still tweet)
NOTE: This is an unreviewed Preprint
Warning: This is a unreviewed preprint (What is a preprint?). Readers are warned that the document has not been peer-reviewed by expert/patient reviewers or an academic editor, may contain misleading claims, and is likely to undergo changes before final publication, if accepted, or may have been rejected/withdrawn (a note "no longer under consideration" will appear above).
Peer review me: Readers with interest and expertise are encouraged to sign up as peer-reviewer, if the paper is within an open peer-review period (in this case, a "Peer Review Me" button to sign up as reviewer is displayed above). All preprints currently open for review are listed here. Outside of the formal open peer-review period we encourage you to tweet about the preprint.
Citation: Please cite this preprint only for review purposes or for grant applications and CVs (if you are the author).
Final version: If our system detects a final peer-reviewed "version of record" (VoR) published in any journal, a link to that VoR will appear below. Readers are then encourage to cite the VoR instead of this preprint.
Settings: If you are the author, you can login and change the preprint display settings, but the preprint URL/DOI is supposed to be stable and citable, so it should not be removed once posted.
Submit: To post your own preprint, simply submit to any JMIR journal, and choose the appropriate settings to expose your submitted version as preprint.
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Impact of Systematic Nursing Education and Psychological Intervention on Anxiety Reduction and Treatment Outcomes in Patients with Xanthelasma Treated with Pingyangmycin Running Title: Findings from a prospective cohort of 228 patients
ABSTRACT
Background:
Xanthelasma palpebrarum (XP) is the most common subtype of cutaneous xanthoma, accounting for more than 95% of cases. Its incidence is increasing and parallels the global rise in obesity. As XP causes conspicuous cosmetic disfigurement, affected patients frequently experience anxiety.
Objective:
In this study, we investigated the efficacy of intralesional pingyangmycin injection for XP and evaluated the impact of systematic nursing education and psychological intervention on anxiety reduction and treatment outcomes.
Methods:
A total of 228 patients with XP (398 lesions) treated between December 2024 and August 2025 were enrolled. All patients underwent intralesional pingyangmycin injection and completed psychological assessments using the Hospital Anxiety and Depression Scale (HADS) at baseline and 1month post-treatment. Systematic nursing education, including injection-related care, postoperative recovery guidance, and emotional support, was provided throughout the treatment process.
Results:
Treatment outcomes showed that 63.31% of lesions achieved complete remission, 23.87% showed improvement, and 2.27% were ineffective. Psychological intervention significantly reduced both anxiety and depression scores (P < 0.001). Furthermore, reductions in anxiety were positively associated with improved treatment outcomes, including a lower incidence of complications and higher patient satisfaction.
Conclusions:
Intralesional pingyangmycin injection is an effective treatment for XP. When combined with psychological intervention and structured nursing education, it not only alleviates anxiety but also enhances treatment compliance and patient satisfaction, thereby optimizing overall therapeutic outcomes.
Citation
Request queued. Please wait while the file is being generated. It may take some time.
Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.