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Accepted for/Published in: JMIR Medical Informatics

Date Submitted: Sep 14, 2025
Date Accepted: Feb 28, 2026

The final, peer-reviewed published version of this preprint can be found here:

Detection of Interpretable and Fine-Grained Brain Tumor Magnetic Resonance Imaging Based on Progressive Pruning: Machine Learning Model Development and Validation Study

Liu Y, Song S, Lian S, Zhang X

Detection of Interpretable and Fine-Grained Brain Tumor Magnetic Resonance Imaging Based on Progressive Pruning: Machine Learning Model Development and Validation Study

JMIR Med Inform 2026;14:e84095

DOI: 10.2196/84095

PMID: 42054652

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Interpretable and Fine-Grained Brain Tumor MRI Detection based on Progressive Pruning

  • Yupeng Liu; 
  • Shuwei Song; 
  • Shibo Lian; 
  • Xiaochen Zhang

ABSTRACT

Brain tumor is one of the most malignant diseases of the central nervous system, and early accurate detection is of great significance for improving patient survival rate. However, the heterogeneity of brain tumors in terms of morphology, size, and location on MRI image, as well as their similarity to surrounding normal brain tissue, poses significant challenges for tumor detection. This paper, based on YOLOv11, proposes a Convolution-Prewitt and Pooling-based Preprocessing (CSPP) which highlights important structural detail more effectively than traditional statistics. A Dynamic Convolution-based C3k2 (DCC) is integrated to more efficiently capture both local and global features. A Channel Prior Convolutional Attention (CPCA) is introduced before the detection head, enabling the network to specifically focus on information-rich channels and key spatial regions. Through Progressive Hybrid Pruning Strategy (PHPS) , the model is lightweighted for efficient inference. Furthermore, Eigen-CAM is utilized to interpret the prediction result, making them more transparent and clinically valuable. On Br35H, mAP50 increased by 2.6%, mAP50:95 increased by 5.9%, and GFLOPs were reduced by 47.7%. On YOLO, mAP50 increased by 19.5%, mAP50:95 increased by 7.7%, and GFLOPs were reduced by 47.7%. On Capstone, mAP50 increased by 6.9%, mAP50:95 increased by 5.8%, and GFLOPs were reduced by 47.7%.


 Citation

Please cite as:

Liu Y, Song S, Lian S, Zhang X

Detection of Interpretable and Fine-Grained Brain Tumor Magnetic Resonance Imaging Based on Progressive Pruning: Machine Learning Model Development and Validation Study

JMIR Med Inform 2026;14:e84095

DOI: 10.2196/84095

PMID: 42054652

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