JMIR Publications

ABSTRACT

Diabetic dyslipidaemia (DD), characterized by a classical triad of abnormal lipid profiles among the diabetes population, presents a major public health concern in South Africa, particularly among Black South Africans. The increasing prevalence of DD significantly contributes to the development of atherosclerotic cardiovascular disease (ACVD). With the incidence of diabetes rising from 4.5% in 2010 to 12.7% by 2021, urgent preventive measures and effective treatments are crucial to tackle the risk of premature mortality. This systematic review and meta-analysis protocol seeks to examine the existing literature on DD to provide an understanding of its prevalence and associated predictors among the diabetic population in South Africa, with the intention of informing more effective clinical and public health interventions. The available literature on DD will be systematically searched in the common scholarly database and reviewed accordingly. All published and un-published studies conducted in South Africa before the year 2024, written in English will be in-cluded. The results of the analysis will aid in crafting the design of targeted interventions and pol-icies to advance the management of DD and, subsequently, to reduce the increased risk of ACVD among the diabetic population. This protocol has been registered in the PROSPERO database (ID: CRD42024614221).