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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Aug 2, 2025
Open Peer Review Period: Aug 3, 2025 - Sep 28, 2025
Date Accepted: Oct 30, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

The Interactive Effects of eHealth Literacy and Mental Health Literacy on Social Media Addiction and Depression-Anxiety-Stress in Adolescents: Cross-Sectional Study

Xu Y, chen z

The Interactive Effects of eHealth Literacy and Mental Health Literacy on Social Media Addiction and Depression-Anxiety-Stress in Adolescents: Cross-Sectional Study

J Med Internet Res 2025;27:e81741

DOI: 10.2196/81741

PMID: 41314644

PMCID: 12701345

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Digital Psychological Immunity: Synergistic Suppression of Multidimensional Health Literacy on Adolescent Social Media Addiction and Depression-Anxiety-Stress

  • Yuting Xu; 
  • zuosong chen

ABSTRACT

Background:

Amid China’s escalating adolescent mental health crisis, exacerbated by digital environments, this study examines how a tripartite health literacy system—comprising eHealth literacy, mental health literacy, and mental eHealth literacy—synergistically mitigates social media addiction and depression-anxiety-stress.

Objective:

Given the compatibility of these theoretical propositions, this study aims to investigate the multifaceted effects and underlying mechanisms of multidimensional health literacy—encompassing Mental Health Literacy, eHealth Literacy, and Mental eHealth Literacy —on adolescent Social Media Addiction and psychological distress (Depression-Anxiety-Stress). The findings will offer a theoretical foundation for developing effective mental health interventions and optimizing adolescent mental health management strategies.

Methods:

A total of 855 high school students (M = 16.38, SD = 0.86) from five provinces in China were recruited using stratified cluster sampling. Standardized scales were employed to assess eHealth literacy, mental health literacy, mental eHealth literacy, social media addiction, and depression-anxiety-stress. Structural equation modeling (SEM) and Hayes' PROCESS macro were used to analyze the data, testing direct, mediating, and moderating effects of the health literacy dimensions.

Results:

The results revealed that both eHealth literacy and mental health literacy directly reduced social media addiction. However, only mental health literacy significantly alleviated depression-anxiety-stress. Mental eHealth literacy was identified as a significant mediator in both pathways. Furthermore, mental health literacy was found to positively moderate the effect of eHealth literacy, creating dual moderated mediation pathways that influenced both addiction and psychological distress.

Conclusions:

This study presents the "Digital Psychological Immunity" framework, elucidating the synergistic role of multidimensional health literacy in mitigating social media addiction and psychological distress. The findings provide theoretical support for national adolescent mental health initiatives, emphasizing the need to concurrently enhance both mental health literacy and digital literacy in addressing the challenges of the digital age. Clinical Trial: This study was approved by the Academic Ethics Committee of Capital University of Physical Education and Sports (Approval No. 2025A0105). All participants provided informed consent prior to participation.


 Citation

Please cite as:

Xu Y, chen z

The Interactive Effects of eHealth Literacy and Mental Health Literacy on Social Media Addiction and Depression-Anxiety-Stress in Adolescents: Cross-Sectional Study

J Med Internet Res 2025;27:e81741

DOI: 10.2196/81741

PMID: 41314644

PMCID: 12701345

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