JMIR Publications

ABSTRACT

Background:

Over 20 million individuals worldwide suffer from sickle cell anemia (SCA), a hereditary condition. It is caused by a mutation in the HBB gene, which results in aberrant hemoglobin S (HbS) synthesis. Two mutant gene copies must exist for the ailment to appear, and it is inherited in an autosomal recessive manner. Because SCA may significantly impair quality of life and cause morbidity, early diagnosis and individualized therapy are essential.

Objective:

1. To analyse age, gender, area and ethnicity distribution in Vidarbha region of patients suffering from SCA 2. To analyse the existing symptoms of SCA 3. To analyse the dietary pattern of SCA patients and corelate clinically with the history of smoke and alcohol (if existed) from existing symptoms.

Methods:

Acharya Vinoba Bhave Rural Hospital (AVBRH), Datta Meghe Institute of Higher Education and Research (DMIHER), Sawangi (M), Wardha, will be the site of this three-month observational research. In order to obtain detailed information from patients for the study, a systematic questionnaire will be used. Age, gender, location, ethnicity, inheritance patterns, symptoms, food choices, and past smoking and alcohol use will be considered important factors. In order to better understand the factors impacting the expression and severity of SCA, the study set out to create a comprehensive clinical profile of SCA patients.

Results:

The results will show that it will be important to identify and monitor SCA, particularly in symptomatic individuals, giving exceptional cases extra consideration. Recurrent episodes of pain, anemia, and possible organ damage all suggestive of the disease's typical vaso-occlusive crises will be observations. A thorough patient history that will address familial incidence, symptom frequency, and previous medical interventions will be crucial for making an accurate diagnosis. This all-encompassing strategy will guarantee a complete comprehension and handling of SCA, stressing the importance of clinical presentation and patient history in successful disease detection and therapy.

Conclusions:

The study evaluates the observational and clinical profiles of patients with SCA, emphasizing the need for comprehensive screening and detailed patient history. Clinical profiles, including recurrent pain, anemia, and organ complications, emphasize the need for ongoing monitoring and tailored treatment strategies.