JMIR Publications

ABSTRACT

Background:

Uptake of the COVID-19 vaccine has been low in the US (about 22% among adults in 2023-241) despite ongoing public health recommendations. This has been linked to many factors including pandemic fatigue, reduced risk perception, dis/misinformation, and more recently, to symptoms of depression and anxiety. Novel communication and messaging strategies are one potential approach to promote vaccine uptake.

Objective:

Randomized control trial testing two communication-based approaches compared to standard public health messaging on vaccine uptake in a cohort of adult US residents.

Methods:

We completed a 3-arm, parallel-group, assessor-blinded stratified-randomized trial between April-15-2024 and May-2-2024. Eligible individuals were ≥18 years old who: 1) had received at least one dose of the COVID-19 vaccine, but, 2) had not received COVID-19 vaccine doses since September-11-2023, and 3) had not been infected with SARS-CoV-2 in the past three months. We purposively sampled eligible individuals with and without symptoms of anxiety and depression. Participants were randomly allocated to: 1) attitudinal inoculation intervention; 2) CBT-kernels intervention; or 3) standard public health messaging intervention.

Results:

At four-week follow up, these groups showed no meaningful differences in uptake (CBT- kernels:1.6% [95%CI:0.4-2.8]; Inoculation:0.9% [95%CI:0.0-1.8]; and Standard:1.3% [95%CI:0.3-2.4]) or level of vaccine willingness.

Conclusions:

Successful efforts to increase uptake of the COVID-19 vaccine via theory-enhanced messaging remain elusive. Clinical Trial: Protocol NCT06119854