Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: JMIR Formative Research

Date Submitted: Jun 11, 2025
Date Accepted: Mar 24, 2026

The final, peer-reviewed published version of this preprint can be found here:

COVID-19 Knowledge, Attitudes, and Practices and Perceived Risk: Cross-Sectional Mixed Methods Study

Ben-Zacharia A, Ben-Zacharia M, Smrtka J

COVID-19 Knowledge, Attitudes, and Practices and Perceived Risk: Cross-Sectional Mixed Methods Study

JMIR Form Res 2026;10:e78563

DOI: 10.2196/78563

PMID: 42155141

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

COVID-19 Knowledge, Attitudes, Practices and Perceived Risk: Cross-Sectional Mixed Methods

  • Aliza Ben-Zacharia; 
  • Moshe Ben-Zacharia; 
  • Jennifer Smrtka

ABSTRACT

Background:

The COVID-19 pandemic has been characterized by miscommunication about the required precautions resulting in public confusion. Knowledge, attitudes, behaviors and perceived risk highlight the importance of education translated into actions to reduce the risk of global infections.

Objective:

The purpose was to investigate the knowledge, attitudes and practices (KAP), and perceived risk associated with COVID-19 among patients with multiple sclerosis (MS), healthcare providers and laypeople during the first 6-months of the pandemic.

Methods:

A descriptive, cross-sectional, partially mixed-methods explanatory sequential design was employed, using convenience sampling. Data were collected through a demographic and a KAP questionnaires including perceived risk assessment. Quantitative data were analyzed with descriptive and inferential statistics, while qualitative comments underwent thematic analysis.

Results:

A total of 148 participants were included: 43 MS patients, 50 healthcare providers, and 55 laypeople. Most participants (90%) possessed basic knowledge about COVID-19. The participants exhibited a range of attitudes and behaviors related to COVID-19. Lay participants have reported mostly a moderate perceived risk for COVID while patients with MS and healthcare providers reported mainly a high perceived risk to contract the virus (X2(6)=12.650, p=.049). Immunosuppressive state and vaccine hesitancy did not predict the COVID perceived risk. Additionally, perceived risk was correlated with the avoidance of crowded and public places. Qualitative analysis revealed themes of uncertainty, anxiety, fear, vulnerability and accountability associated with the perceived risk of contracting COVID-19.

Conclusions:

COVID-19 knowledge is linked to positive attitudes and preventive behaviors. To address future pandemic threats, KAP-focused educational and public health initiatives are essential in fostering appropriate health behaviors.


 Citation

Please cite as:

Ben-Zacharia A, Ben-Zacharia M, Smrtka J

COVID-19 Knowledge, Attitudes, and Practices and Perceived Risk: Cross-Sectional Mixed Methods Study

JMIR Form Res 2026;10:e78563

DOI: 10.2196/78563

PMID: 42155141

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.