JMIR Publications

ABSTRACT

Background:

Treatment of Helicobacter pylori (H. pylori) infection often fails to achieve optimal eradication rates, due to poor patient compliance. Although various intensive educational interventions have been developed to improve compliance, the effectiveness of new media-based education (NME) remains uncertain.

Objective:

This meta-analysis aims to evaluate the impact of new media education on H. pylori treatment outcomes.

Methods:

A comprehensive search was conducted across electronic databases (PubMed, EMBASE, Web of Science, and Cochrane Library) for randomized controlled trials (RCTs) and retrospective cohort studies focusing on NME for H. pylori-infected patients from inception to February 2025. The primary outcomes included eradication rate and treatment compliance, while secondary outcomes included adverse drug reactions and patient satisfaction. Risk ratios (RRs) with 95% confidence intervals were calculated. Sensitivity and subgroup analyses were performed.

Results:

13 relevant studies involving a total of 2,942 patients were included. Compared to the control group, NME significantly increased H. pylori eradication rate (81.9% vs. 67.0%, RR=1.22, 95% CI: 1.11-1.33) and treatment compliance (90.5% vs. 73.0%, RR=1.27, 95% CI: 1.15-1.40). Subgroup analysis showed higher eradication rates and patient compliance in the WeChat and quadruple therapy subgroups (p < 0.05). No significant difference was found in adverse reactions (RR=0.88, 95% CI: 0.71-1.09, p=0.23), but patient satisfaction was higher in the NME group (61.0% vs. 47.7%, RR=1.30, 95% CI: 1.13-1.49, p=0.0002).

Conclusions:

NME significantly enhances H. pylori eradication rates, treatment compliance, and patient satisfaction, especially when using platforms such as WeChat and in combination with quadruple therapy.