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Previously submitted to: JMIR AI (no longer under consideration since Apr 22, 2026)

Date Submitted: May 26, 2025

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

From Hallucinations to Help: Can Retrieval‑Augmented Generation (RAG) Deliver Trustworthy Clinical Artificial Intelligence?

  • Prajita Niraula; 
  • Mallika Upreti; 
  • Suman Kadariya; 
  • Bishal Poudel; 
  • Sujan Kadariya; 
  • Shreedhar Shreedhar Kunwar; 
  • Satenla Ruit

ABSTRACT

KEY MESSAGES Standalone AI systems risk clinical harm due to inaccuracies (“hallucinations”) and biases, limiting their reliability for diagnosis or documentation. Retrieval-augmented generation (RAG) improves safety by grounding AI outputs in real-time medical evidence, but its success hinges on high-quality data and equitable design. Policymakers must prioritize adaptive regulation, including standardized bias audits, interoperability standards, and global access to prevent AI from exacerbating healthcare disparities. Clinicians, not AI, must retain final authority; RAG tools should augment judgment with explainable, verifiable recommendations while minimizing workflow disruption.


 Citation

Please cite as:

Niraula P, Upreti M, Kadariya S, Poudel B, Kadariya S, Shreedhar Kunwar S, Ruit S

From Hallucinations to Help: Can Retrieval‑Augmented Generation (RAG) Deliver Trustworthy Clinical Artificial Intelligence?

JMIR Preprints. 26/05/2025:78107

DOI: 10.2196/preprints.78107

URL: https://preprints.jmir.org/preprint/78107

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