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Accepted for/Published in: JMIR Serious Games

Date Submitted: May 22, 2025
Date Accepted: Sep 30, 2025

The final, peer-reviewed published version of this preprint can be found here:

Immersive Virtual Reality–Assisted Therapy for Distressing Voices in Psychosis: Qualitative Study of Participants’ and Therapists’ Experiences in the Challenge Trial

Christensen MJ, Rydborg MP, Jørgensen R, Nielsen CD, Mainz J, Bell IH, Thomas N, Smith LC, Mariegaard LS, Ward T, Nordentoft M, Glenthøj LB, Vernal DL

Immersive Virtual Reality–Assisted Therapy for Distressing Voices in Psychosis: Qualitative Study of Participants’ and Therapists’ Experiences in the Challenge Trial

JMIR Serious Games 2025;13:e77920

DOI: 10.2196/77920

PMID: 41328520

PMCID: 12670062

Immersive virtual reality-assisted therapy for distressing voices in psychosis: A qualitative study of participants’ and therapists’ experiences in the Challenge trial

  • Mads Juul Christensen; 
  • Matilde Poulsen Rydborg; 
  • Rikke Jørgensen; 
  • Cecilie D. Nielsen; 
  • Jan Mainz; 
  • Imogen H. Bell; 
  • Neil Thomas; 
  • Lisa Charlotte Smith; 
  • Lise S. Mariegaard; 
  • Thomas Ward; 
  • Merete Nordentoft; 
  • Louise Birkedal Glenthøj; 
  • Ditte Lammers Vernal

ABSTRACT

Background:

Virtual reality-assisted therapy (VRT) for distressing voices in psychosis is a variant of AVATAR therapy (AT) that uniquely incorporates immersive virtual reality (VR) to facilitate dialogue with a digital representation of a voice, unlike original AT which does not use VR. While previous research from the AVATAR trial has explored participants' experiences with AT, no qualitative studies have investigated therapists’ perspectives or focused specifically on VRT.

Objective:

The present study aimed to explore both participants´ experiences of receiving VRT and therapists´ experiences of delivering VRT within the Challenge trial.

Methods:

This qualitative study conducted semi-structured interviews with 10 trial participants and 8 therapists from the Challenge trial. Selection criteria of VRT trial participants included recruitment site and voice-hearing duration. Interviews were audio-recorded, transcribed, and subjected to thematic analysis. Reporting follows SRQR (i.e. Standards of Reporting Qualitative Research).

Results:

Analysis led to five overarching themes: (1) Using technology to meet the voice, (2) A different approach to voice-hearing and treatment, (3) Limitations, obstacles, and adaptations, (4) Changes, mechanisms and prerequisites, and (5) A price to pay. VRT was generally perceived as acceptable, appropriate, and feasible. However, some areas required attention, including trial participant anxiety, negative voice reactions, optimization of immersion, technical malfunctions, time restraints, and availability of organizational resources. Notably, therapists’ extra efforts helped overcome these barriers to effective VRT delivery.

Conclusions:

The results highlight VRT’s potential for positive outcomes in alleviating distressing voices. However, challenges such as trial participant anxiety, negative voice reactions, and therapists' struggles with technology issues must be addressed in future research, trials, or in implementation efforts.


 Citation

Please cite as:

Christensen MJ, Rydborg MP, Jørgensen R, Nielsen CD, Mainz J, Bell IH, Thomas N, Smith LC, Mariegaard LS, Ward T, Nordentoft M, Glenthøj LB, Vernal DL

Immersive Virtual Reality–Assisted Therapy for Distressing Voices in Psychosis: Qualitative Study of Participants’ and Therapists’ Experiences in the Challenge Trial

JMIR Serious Games 2025;13:e77920

DOI: 10.2196/77920

PMID: 41328520

PMCID: 12670062

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