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Currently accepted at: JMIR Cardio

Date Submitted: May 30, 2025
Date Accepted: Oct 20, 2026

This paper has been accepted and is currently in production.

It will appear shortly on 10.2196/77896

The final accepted version (not copyedited yet) is in this tab.

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

AI-Enabled Tailored Messaging Around Cardiovascular Health Increases Engagement

  • Aubree Xia; 
  • Kumar Thurimella; 
  • Sheana Bull; 
  • Joy Waughtal; 
  • Catia Chavez; 
  • Sylvie Novins-Montague; 
  • Joshva Silvasstar; 
  • Adam Salyers; 
  • P. Michael Ho; 
  • Mariel Lavieri

ABSTRACT

Background:

Cardiovascular (CV) disease risk factors disproportionately affect underserved populations, emphasizing the need for innovative self-management support. This pilot randomized trial evaluated AI-enabled text messaging interventions based on the American Heart Association's Life’s Essential 8 (LE8) framework across three Federally Qualified Health Systems.

Objective:

To assess participant engagement with AI-enabled text messaging based on a variety of factors including language, timing of messages, and message topic.

Methods:

Participants were randomized into three groups: generic messages, AI chatbot-tailored messages with behavioral nudges, and AI chatbot messages supplemented by pharmacist engagement.

Results:

Preliminary findings showed higher engagement with lifestyle topics (diet, physical activity, weight management) compared to health-related content (blood pressure, blood glucose, cholesterol and medicine), with no significant differences between English- and Spanish-speaking participants or across patients with different CV diseases. A significant difference in the interaction, measured as the number of incoming text message patient responses was observed between weekdays and weekends (U = 243, p < 0.01). The AI chatbot (without a pharmacist) arm demonstrated significantly higher response rates than the generic message group (p=0.0102), highlighting the potential of conversational AI to enhance patient interaction.

Conclusions:

These results underscore the promise of AI-driven messaging systems in addressing CV disease risk factors in underserved populations and suggest that future research should focus on personalization, and optimizing message delivery timing. Clinical Trial: ClinicalTrials.gov ID: NCT06324981


 Citation

Please cite as:

Xia A, Thurimella K, Bull S, Waughtal J, Chavez C, Novins-Montague S, Silvasstar J, Salyers A, Ho PM, Lavieri M

AI-Enabled Tailored Messaging Around Cardiovascular Health Increases Engagement

JMIR Preprints. 30/05/2025:77896

DOI: 10.2196/preprints.77896

URL: https://preprints.jmir.org/preprint/77896

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