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Accepted for/Published in: JMIR Medical Informatics

Date Submitted: May 20, 2025
Date Accepted: Dec 24, 2025

The final, peer-reviewed published version of this preprint can be found here:

Enhancing Anesthetic Depth Assessment via Unsupervised Machine Learning in Processed Electroencephalography Analysis: Novel Methodological Study

Huang PY, Hong WL, Hee HZ, Chang WK, Lee CH, Ting CK

Enhancing Anesthetic Depth Assessment via Unsupervised Machine Learning in Processed Electroencephalography Analysis: Novel Methodological Study

JMIR Med Inform 2026;14:e77830

DOI: 10.2196/77830

PMID: 41650286

PMCID: 12880611

Enhancing anesthetic depth assessment via unsupervised machine learning in processed electroencephalography analysis: a novel methodological study

  • Po-Yu Huang; 
  • Wei-Lun Hong; 
  • Hui-Zen Hee; 
  • Wen-Kuei Chang; 
  • Ching-Hung Lee; 
  • Chien-Kun Ting

ABSTRACT

Background:

General anesthesia induces temporary loss of consciousness, and electroencephalography (EEG)-based monitoring is crucial for tracking this state. However, EEG-based indices that are used to assess the depth of anesthesia can be influenced by various factors, potentially leading to misleading outputs.

Objective:

This study aimed to explore the feasibility of using unsupervised machine learning on processed EEG data to enhance anesthetic depth assessment.

Methods:

Over 16,000 data points were collected from patients who underwent elective lumbar spine surgery. The EEG data were processed using a bandpass filter and Fast Fourier Transform for power spectral density estimation. Unsupervised machine learning with Fuzzy C-means clustering was applied to categorize anesthesia depth into three clusters: slight, proper, and deep.

Results:

Fuzzy C-means clustering identified distinct anesthesia depth groups based on delta, alpha, theta, and beta band power ratios. Visual representations validated the clustering results, which were consistent across individual patient data. The figures demonstrate the application of clustering to EEG data, revealing detailed anesthesia depth estimations.

Conclusions:

This study developed a machine learning-based methodology for anesthesia depth assessment, demonstrating feasibility and providing preliminary insights into classification, visualization, and patient-specific management. By applying Fuzzy C-Means clustering to processed EEG data, this approach enhances anesthesia depth understanding and integrates with existing monitoring modalities.


 Citation

Please cite as:

Huang PY, Hong WL, Hee HZ, Chang WK, Lee CH, Ting CK

Enhancing Anesthetic Depth Assessment via Unsupervised Machine Learning in Processed Electroencephalography Analysis: Novel Methodological Study

JMIR Med Inform 2026;14:e77830

DOI: 10.2196/77830

PMID: 41650286

PMCID: 12880611

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