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Accepted for/Published in: JMIR Cancer

Date Submitted: Apr 22, 2025
Date Accepted: Sep 16, 2025

The final, peer-reviewed published version of this preprint can be found here:

Integrated, Cross-Entity Information on Preventive Measures for Bowel, Breast, and Prostate Cancer: Evaluation Study of the Web Application “Prevent-Take-Up”

Kestler AM, Schwab JD, Jähnig T, Melzer MK, Zengerling F, Lukac S, Janni W, Bolenz C, Barzel A, Kestler HA, Seufferlein T

Integrated, Cross-Entity Information on Preventive Measures for Bowel, Breast, and Prostate Cancer: Evaluation Study of the Web Application “Prevent-Take-Up”

JMIR Cancer 2025;11:e76393

DOI: 10.2196/76393

PMID: 41259673

PMCID: 12630371

Integrated, cross-entity information on preventive measures for bowl, breast, and prostate cancer: evaluation study of a web application “Prevent-Take-Up”

  • Angelika M.R. Kestler; 
  • Julian D. Schwab; 
  • Tanja Jähnig; 
  • Michael Karl Melzer; 
  • Friedemann Zengerling; 
  • Stefan Lukac; 
  • Wolfgang Janni; 
  • Christian Bolenz; 
  • Anne Barzel; 
  • Hans A. Kestler; 
  • Thomas Seufferlein

ABSTRACT

Background:

About 40% of cancers could be prevented by evidence-based means, but their uptake is still improvable. A tool offering easy-to-access, multi-entity, and individualized information on primary and secondary preventive measures could improve informed decisions and increase uptake.

Objective:

Prevent-Take-Up is an interactive web application (WebApp) providing guideline-based, risk-adapted information on such measures for colorectal, breast, and prostate cancer. Following a questionnaire, it may recommend to seek further information from a GP or a specialist.

Methods:

Prevent-Take-Up was designed based on German S3 guidelines, revised after feedback from two focus groups (10 patients, 11 consultants from general medicine, urology, gynecology, and gastroenterology) and then made publicly available to the screening population. We report the evaluation of the revised WebApp by the first 101 users (62 women, 38 men, one unspecified; age mainly between 50 and 70 years). Data were collected in 2022-2023 and evaluated in 2024.

Results:

Satisfaction on a five-point Likert scale was high regarding user-friendliness (f: 76%, m: 65%), comprehensibility of the questions (f: 87%, m: 83%), and recommendations provided (f: 76%, m: 63%). 59% of females and 44% of males appreciated the WebApp functionality, 47% of females and 37% of males reported improved knowledge of prevention/early detection of colorectal, breast, and prostate cancer. 71% of females and 47% of males were prepared to follow up on WebApp recommendations and seek more information from their GPs.

Conclusions:

A WebApp for risk-adapted prevention across multiple entities can be successfully implemented and achieves promising satisfaction ratings in the population concerned.


 Citation

Please cite as:

Kestler AM, Schwab JD, Jähnig T, Melzer MK, Zengerling F, Lukac S, Janni W, Bolenz C, Barzel A, Kestler HA, Seufferlein T

Integrated, Cross-Entity Information on Preventive Measures for Bowel, Breast, and Prostate Cancer: Evaluation Study of the Web Application “Prevent-Take-Up”

JMIR Cancer 2025;11:e76393

DOI: 10.2196/76393

PMID: 41259673

PMCID: 12630371

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