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Accepted for/Published in: JMIR Formative Research

Date Submitted: Apr 19, 2025
Open Peer Review Period: Apr 21, 2025 - Jun 16, 2025
Date Accepted: Oct 13, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Depression and Anxiety Outcomes in a Technology-Enabled Psychotherapy Practice: Retrospective Cohort Study

Forand NR, Nettiksimmons J, Anton M, Truxson R, Vanderwood K, Green B

Depression and Anxiety Outcomes in a Technology-Enabled Psychotherapy Practice: Retrospective Cohort Study

JMIR Form Res 2025;9:e76264

DOI: 10.2196/76264

PMID: 41330576

PMCID: 12709161

Outcomes of Technology-Enabled Psychotherapy Practice at Scale

  • Nicholas R. Forand; 
  • Jasmine Nettiksimmons; 
  • Margaret Anton; 
  • Raven Truxson; 
  • Karl Vanderwood; 
  • Brandn Green

ABSTRACT

Background:

Mental health conditions account for significant distress, burden, and societal costs. Despite efforts to implement evidence-based practices, access to high quality mental health treatment in general practice remains limited, and clinical outcomes sub-optimal. Measurement-based care (MBC) is a transtheoretical and transdiagnostic strategy that has the potential, when implemented effectively, to improve the quality of care. Digital tools can also support clinicians by alleviating administrative tasks and providing in-the-moment performance data and clinical decision support. In this study, we examine the clinical outcomes of a technology-enabled psychotherapy practice, where clinicians are supported by a suite of innovations including an MBC platform, clinical decision support tools, and tools designed to alleviate administrative burden.

Objective:

The current study examines client retention and depression and anxiety outcomes within a technology enabled psychotherapy practice.

Methods:

This retrospective cohort study examines 2,984 adults who initiated mental health treatment with Two Chairs, a hybrid technology enabled behavioral health provider, between January 1 to June 30, 2024. Rates of reliable change, recovery, remission, and magnitude and trajectory of symptom change in depression and anxiety symptoms were assessed using the PHQ-9 and GAD-7.

Results:

The population demonstrated high rates of retention in care (89.9%), as well as high rates of MBC survey completion (96.3%). From baseline to the 12th session, patients showed significant symptom improvements in depression and anxiety, achieving high rates of reliable improvement (65.8%) and recovery (53.2%). Aggregate clinical outcomes continued to improve up to the point of termination. Pre to post-treatment effect sizes were large (all Cohen’s d’s > 0.9).

Conclusions:

This study demonstrates how technology-enabled measurement-based care and clinical decision support systems may drive high quality patient outcomes in mental health. Implications for healthcare costs and value-based payment models are discussed.


 Citation

Please cite as:

Forand NR, Nettiksimmons J, Anton M, Truxson R, Vanderwood K, Green B

Depression and Anxiety Outcomes in a Technology-Enabled Psychotherapy Practice: Retrospective Cohort Study

JMIR Form Res 2025;9:e76264

DOI: 10.2196/76264

PMID: 41330576

PMCID: 12709161

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