JMIR Publications

ABSTRACT

Background:

Young African American men who have sex with men (AAMSM) experience disproportionately high HIV incidence and are less likely to achieve viral suppression compared to White MSM, an outcome that relies on antiretroviral therapy (ART) adherence. We created My Personal Health Guide, a talking relational agent-based mobile health (mHealth) app to improve ART adherence among young AAMSM.

Objective:

The objective was to determine the efficacy of My Personal Health Guide on improving ART adherence among young AAMSM living with HIV.

Methods:

We implemented a randomized controlled trial (RCT) among young (18-34 years) AAMSM with non-optimal ART adherence throughout the United States between February 2020 and September 2023, predominantly through social media, and by word of mouth, provider referral, and fliers in selected healthcare settings. Participants were randomized in a 1:1 ratio using permuted blocks of 8 to the intervention, My Personal Health Guide, or attention control arm. ART adherence was assessed with Wilson’s 3-item self-reported adherence measurement and dichotomized at >80%. Logistic regression models using backward selection were employed to evaluate the efficacy of My Personal Health Guide on >80% ART adherence at 1-month follow-up.

Results:

Among the 253 AAMSM at baseline, most (71.1%) self-reported being >80% adherent to ART, over half (57.3%) resided in the Southern United States but all U.S. regions were represented, nearly half (42.3%) had some college education, over one-third (37.9% ) had less than optimal literacy, and approximately one-quarter (24.1%) experienced housing insecurity in the past 6 months. The sample for analysis of My Personal Health Guide app efficacy was 131 (76 intervention: 55 control). The odds of being >80% adherent to ART at 1-month follow-up was 3.97 times greater (95% CI: 1.26, 12.55) among participants randomized to the My Personal Health Guide app compared to the controls, after adjusting for ART adherence at baseline, treatment adherence self-efficacy, and ever being incarcerated. Additionally, for every one-point increase in the HIV-ASES increased the odds of >80% ART adherence by 3% (OR: 1.03; 95% CI: 1.00-1.06).

Conclusions:

Participants randomized to receive My Personal Health Guide reported nearly four times greater odds of being >80% adherent to ART compared to the attention control group at 1-month follow-up. To our knowledge, this is the first RCT demonstrating improved medication adherence using a relational agent-based behavioral intervention. These findings provide evidence of short-term efficacy of My Personal Health Guide to improve ART adherence among young AAMSM. We recommend further research of the inclusion of relational agents in behavioral research, especially in populations affected by stigma and non-optimal health literacy where this nonhuman supportive and educational approach may be complementary to healthcare systems. Clinical Trial: National Institute of Mental Health (R01MH116721)