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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Mar 6, 2025
Open Peer Review Period: Mar 7, 2025 - May 2, 2025
Date Accepted: Oct 20, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Using Generative AI to Co-Design Digital Mental Health Interventions With Adolescents in Rural South Africa: Qualitative Thematic Analysis of Participatory Workshops

Dallison S, Moffett B, Makhubela P, Nkuna T, Pozuelo JR, van Heerden A, O'Mahen H

Using Generative AI to Co-Design Digital Mental Health Interventions With Adolescents in Rural South Africa: Qualitative Thematic Analysis of Participatory Workshops

J Med Internet Res 2025;27:e73535

DOI: 10.2196/73535

PMID: 41348954

PMCID: 12680127

Using Generative AI to Co-design Digital Mental Health Interventions With Adolescents: A Thematic Analysis of Participatory Workshops in Rural South Africa

  • Sophie Dallison; 
  • Bianca Moffett; 
  • Princess Makhubela; 
  • Tamera Nkuna; 
  • Julia R. Pozuelo; 
  • Alastair van Heerden; 
  • Heather O'Mahen

ABSTRACT

Background:

The Kuamsha app was originally developed for a two-arm randomised controlled pilot trial (the DoBAt study), which assessed the feasibility, acceptability, and initial efficacy of a digital choose-your-own-adventure style serious game that delivered behavioural activation (BA) therapy to adolescents with depression in rural South Africa.

Objective:

This qualitative study explored the role of generative artificial intelligence (AI) as a novel method of developing engaging, relatable, and relevant digital mental health content for adolescents in rural South Africa.

Methods:

Through interactive, exploratory workshops and focus group discussions, adolescents compared stories, images, and songs created by generative AI to those in the Kuamsha app, a digital mental health intervention developed without AI.

Results:

Inductive thematic analysis revealed three themes: ‘Use of generative AI tools in a workshop’, ‘Reflections on the creations and comparison’ and ‘Thinking towards the future’. Adolescents generally showed a preference for AI-generated media compared to the Kuamsha app media, and the creative process was an important aspect of the process for adolescents.

Conclusions:

This study highlighted current biases of existing generative AI tools while also demonstrating the significant potential of generative AI to enhance ‘real-time’ co-design of digital mental health interventions by incorporating more culturally relevant and personalised content.


 Citation

Please cite as:

Dallison S, Moffett B, Makhubela P, Nkuna T, Pozuelo JR, van Heerden A, O'Mahen H

Using Generative AI to Co-Design Digital Mental Health Interventions With Adolescents in Rural South Africa: Qualitative Thematic Analysis of Participatory Workshops

J Med Internet Res 2025;27:e73535

DOI: 10.2196/73535

PMID: 41348954

PMCID: 12680127

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