Accepted for/Published in: JMIR Research Protocols
Date Submitted: Mar 5, 2025
Date Accepted: May 29, 2025
The impact of the exposome in type 1 diabetes: a scoping review protocol
ABSTRACT
Background:
The recent increase in the incidence of type 1 diabetes over the past few decades has been too rapid to be explained solely by genetic factors. It is likely influenced by environmental factors as well. Understanding these environmental factors, the exposome, is essential for identifying new disease prevention and management strategies. This paper aims to present a protocol for a scoping review to gather current knowledge on the various dimensions of the exposome relevant to the development and outcomes of T1D.
Objective:
This scoping review aims to gather current knowledge on the multidimensional nature and interactions of the exposome and its relation to T1D, highlight existing knowledge gaps, and provide a foundation for future research.
Methods:
We will follow principles from the JBI methodology for scoping reviews and the PRISMA-ScR guidelines. We will search for relevant publications in five databases: PubMed, Embase (Elsevier), CINHAL (EBSCO), Web of Science (Clarivate) and Google Scholar. All articles about the impact of environmental exposures on the development or outcomes of T1D will be collected. Two independent reviewers will then use the CADIMA web tool to screen records for titles, abstracts and full texts before data extraction and synthesis of all relevant results. This scoping review is registered with the OSF, under the following DOI: 10.17605/OSF.IO/UJ5KM.
Results:
This scoping review is currently ongoing. It is expected to be completed in November 2025. The results will be released as a peer-reviewed open-access publication.
Conclusions:
This scoping review will help the scientific community understand the various aspects of the exposome in the development of T1D and its consequences.
Citation
Request queued. Please wait while the file is being generated. It may take some time.
Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.