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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Feb 26, 2025
Open Peer Review Period: Feb 27, 2025 - Apr 24, 2025
Date Accepted: Sep 22, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Human-Delivered Conversation Versus AI Chatbot Conversation in Increasing Heart Attack Knowledge in Women in the United States: Quasi-Experimental Studies

Kim DD, Zhang J, Sagae K, DeVon HA, Hoffmann TJ, Rountree L, Fukuoka Y

Human-Delivered Conversation Versus AI Chatbot Conversation in Increasing Heart Attack Knowledge in Women in the United States: Quasi-Experimental Studies

J Med Internet Res 2025;27:e73184

DOI: 10.2196/73184

PMID: 41105851

PMCID: 12538107

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Comparison of Human-Delivered Conversation versus AI Chatbot Conversation in Increasing Heart Attack Knowledge in Women in the United States

  • Diane Dagyong Kim; 
  • Jingwen Zhang; 
  • Kenji Sagae; 
  • Holli A. DeVon; 
  • Thomas J. Hoffmann; 
  • Lauren Rountree; 
  • Yoshimi Fukuoka

ABSTRACT

Background:

Artificial intelligence (AI) chatbots, driven by advances in natural language processing (NLP), can analyze and generate human language through computational linguistics and machine learning. Despite the rapid development of large language models, little investigation has been conducted to assess whether AI chatbot-delivered educational conversation can achieve a similar level of efficacy as human-delivered conversation.

Objective:

To evaluate and compare the potential efficacy of human-delivered conversation versus AI chatbot conversation in increasing women’s knowledge and awareness of symptoms and response to heart attack in the United States.

Methods:

This is a secondary analysis of two data sets collected from the AI Chatbot Development Project. Women aged 25 years or older were recruited through flyers and social media. The first dataset contained conversational data where a human researcher engaged in educational conversations with women (Human dataset), whereas the second dataset contained conversational data where an AI chatbot named HeartBot engaged in the same educational conversations with women (HeartBot dataset). Knowledge and awareness of symptoms and response to heart attack were measured at the pre-and post-interaction with either the human or HeartBot. Perceived message effectiveness and conversational quality were measured at the post-survey. Ordinal logistic regression analyses were conducted to explore factors predicting women’s knowledge, adjusting for age, race/ethnicity, interaction group type, education, word count, message effectiveness, and message humanness.

Results:

A total of 171 women (mean age=41 years, SD=12.08) in the Human dataset and 104 women (mean age=46 years, SD=11.86) in the HeartBot dataset completed the baseline survey. Both human-delivered conversations and HeartBot conversation significantly improved participants’ ability to recognize heart attack symptoms (AOR 15.19, 95% CI 8.46-27.25, p=0.000000000000000000075; AOR 7.18, 95% CI 3.59-14.36, p=0.000000025), differentiate between symptoms (AOR 9.44, 95% CI 5.60-15.91, p=0.000000000000000034; AOR 5.44, 95% CI 2.76-10.74, p=0.0000011), call emergency services (AOR 6.87, 95% CI 4.09-11.05, p= 0.000000000000035; AOR 5.74, 95% CI 2.84-11.60, p= 0.0000011), and seek emergency care within 60 minutes of symptom onset (AOR 8.68, 95% CI 4.98-15.15, p=0.000000000000027; AOR 2.86, 95% CI 1.55-5.28, p=0.00078) respectively, even after adjusting for covariates. Comparing the two via interaction tests showed a statistically significant improvement of human-delivered conversation vs. HeartBot conversation for all but the calling an ambulance question (p=0.089).

Conclusions:

Our findings indicate that HeartBot holds promise in increasing heart attack knowledge and awareness among women in a cost-effective manner. Future research should employ rigorous experimental designs, such as randomized controlled trials, and evaluate their effectiveness in improving heart health knowledge and subsequent behavior changes.


 Citation

Please cite as:

Kim DD, Zhang J, Sagae K, DeVon HA, Hoffmann TJ, Rountree L, Fukuoka Y

Human-Delivered Conversation Versus AI Chatbot Conversation in Increasing Heart Attack Knowledge in Women in the United States: Quasi-Experimental Studies

J Med Internet Res 2025;27:e73184

DOI: 10.2196/73184

PMID: 41105851

PMCID: 12538107

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