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Accepted for/Published in: JMIR Cancer

Date Submitted: Feb 19, 2025
Date Accepted: Nov 19, 2025

The final, peer-reviewed published version of this preprint can be found here:

ChatGPT Versus DeepSeek for Breast Cancer Information Retrieval: Quantitative Comparative Study

Hajjo R, Sabbah DA, Bardaweel SK

ChatGPT Versus DeepSeek for Breast Cancer Information Retrieval: Quantitative Comparative Study

JMIR Cancer 2026;12:e72839

DOI: 10.2196/72839

PMID: 41773687

PMCID: 12954694

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

ChatGPT vs. DeepSeek: A Comparative Analysis of AI Models for Breast Cancer Information Retrieval

  • Rima Hajjo; 
  • Dima A. Sabbah; 
  • Sanaa K. Bardaweel

ABSTRACT

Artificial intelligence (AI) has revolutionized biomedicine, driving advancements in diagnostics, treatment, and medical data management. Breast cancer, a significant global health challenge, highlights the need for accessible and reliable medical information. AI platforms like ChatGPT-4.0 and DeepSeek-V3 have become essential tools for delivering curated medical insights. This study compared ChatGPT-4.0 and DeepSeek-V3 in retrieving and presenting medical information, focusing on readability, content quality, and reliability of information sources. Using Flesch-Kincaid Grade Level (FKGL) and a 7-point Likert scale, the analysis revealed that AI models often produce simpler responses than expert references, improving accessibility but risking oversimplification. ChatGPT demonstrated greater consistency and improved readability in multi-response scenarios, excelling in clarity and depth, while DeepSeek aligned more closely with expert reference readability in single-instance analysis but showed higher variability. DeepSeek excelled in citation efficiency and global reference diversity, but faced challenges like untagged links, corrupted references, and occasional downtime. Despite these differences, statistical analysis showed no significant differences between the models, particularly in larger datasets. Both models provided reliable information, but no single model consistently matched expert content across all questions. The findings reveal that no single AI model consistently matches expert content across all questions, emphasizing the need for careful evaluation to ensure AI-generated information meets diverse user needs. Future improvements should focus on enhancing link accessibility, platform stability, and response consistency to optimize AI-generated medical content for healthcare applications.


 Citation

Please cite as:

Hajjo R, Sabbah DA, Bardaweel SK

ChatGPT Versus DeepSeek for Breast Cancer Information Retrieval: Quantitative Comparative Study

JMIR Cancer 2026;12:e72839

DOI: 10.2196/72839

PMID: 41773687

PMCID: 12954694

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