Accepted for/Published in: JMIR Aging
Date Submitted: Feb 19, 2025
Open Peer Review Period: Feb 18, 2025 - Apr 15, 2025
Date Accepted: Apr 28, 2025
(closed for review but you can still tweet)
Longitudinal remote sleep and cognitive research in older adults with mild cognitive impairment and dementia: a prospective feasibility cohort study
ABSTRACT
Background:
Sleep holds promise as a modifiable risk factor for neurodegenerative diseases and dementia. Clinical trials to modify sleep in people at-risk or at early stages of dementia are needed. Monitoring naturalistic sleep from home would support pragmatic and decentralised large-scale clinical trials. However, whether longitudinal sleep research can be successfully delivered remotely in this population had not yet been established.
Objective:
We investigated the feasibility of remote longitudinal research using wearable devices and smartphone applications to record sleep and cognition in older adults with mild cognitive impairment (MCI) or dementia.
Methods:
Older adults with MCI or dementia due to Alzheimer’s disease (AD) or Lewy body disease (LBD) and cognitively healthy participants completed at-home sleep and circadian monitoring (digital sleep diaries, actigraphy, wearable sleep electroencephalography (EEG), saliva samples) and digital cognitive assessments for 8 weeks. Feasibility outcomes included recruitment, retention, and data completeness.
Results:
41 participants consented (10 AD, 11 LBD, and 20 controls) and 40 completed the 8-week study. Data completeness for sleep EEG was 91% and ranged from 79% to 97% for all remote tasks. 12/40 (30%) participants reported receiving external support with completing study tasks.
Conclusions:
Longitudinal multimodal sleep and cognitive profiling using novel technology is feasible in older adults with MCI and dementia and healthy older adults.
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Copyright
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