Previously submitted to: JMIR Research Protocols (no longer under consideration since Aug 11, 2026)
Date Submitted: Feb 7, 2025
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Evaluation of Salivary and Serum levels of Leptin and Adiponectin in patients with Stage I-IV Periodontitis: A Protocol for Systematic Review and Meta-analysis
ABSTRACT
Background:
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth and has been closely related to systemic conditions such as obesity, diabetes, and cardiovascular diseases. Adipokines that plays crucial role in inflammation as well as immune regulation includes, leptin and adiponectin. The relationship between adipokines and periodontitis may help in providing identification of disease biomarkers for its diagnosis and prognosis.
Objective:
We aims to investigate the relationship the severity of periodontitis and the levels of adipokines including, leptin and adiponectin.
Methods:
The authors will search PubMed, Cochrane Library, and Embase with no language limits. Reviewers will also hand search and review bibliographies of relevant articles, check trial registers for ongoing trials, and check for potentially relevant research. Keywords to be used in the search are adipokines, leptin, adiponectin, and Periodontitis. Those RCTs will be included, wherein an open or blinded assessment of outcomes has been done. In addition, full-length journal publications reporting will also be included. Brief abstracts, which are mostly reports of meetings, nonrandomized studies, those on experimental pain and those with animal models, and observational studies will be excluded. For each study, eligibility will be determined separately by three review authors. Risk of Bias (RoB) shall be assessed for each study in accordance with established Cochrane methodology.
Results:
The severity of periodontitis and the association systemic levels of liptin and adiponectine will be evaluated and the possible mechanism between them will be beneficial for advance diagnostic and prognostic biomarkers.
Conclusions:
This study aims to assess whether levels of leptin and adiponectine has the potential role in the severity of periodontitis. If we find positive correlation, the results will help in finding the novel salivary and serum biomarkers for advance diagnosis and prevention of the disease. Results from this study will be published in national and international academic journals. Clinical Trial: Prospero CRD42024541600; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024541600
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Copyright
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