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The rs243865 Polymorphism In Matrix Metalloproteinase 2 And Its Association With Target Organ Damage In Resistant Hypertension Patients
ABSTRACT
Background:
Resistant hypertension presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of Matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage. Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in resistant hypertension remains inadequately defined.
Objective:
This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and in patients with resistant hypertension (RH), underscoring its critical role as a genetic determinant of target organ damage (TOD).
Methods:
A cross-sectional study with both descriptive and analytical components, in 78 patients with resistant hypertension at the Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital from July 2023 to February 2024.
Results:
More than three-quarters of RH patients had carotid-femoral PWV >10 m/s and microalbuminuria at prevalence of 79.5% and 75.6%, respectively. And more than half of RH patients had LVMI, relative wall thickness and carotid artery stenosis with the prevalence of 56.4%, 55.1% and 52.6%, respectively. Of 78 studied resistent hypertension patients, the presence of genotype CC was 76.9%, genotype CT accounted for 20.5% and 2.6% of genotype TT. The percentage of SNP rs243865(-1306C>T) carring allele T was 23.1%. The MMP-2 gene polymorphism 1306C/T (rs243865) was significantly associated with EF and carotid artery stenosis with OR (95%CI) of 8.1(1.3-51.4); p=0.026 and 4.5(1.1-20.1); p=0.048 respectively. The allele T was found to be significantly associated with arterial stiffness including Brachial-ankle PWV and Carotid-Femoral PWV with the correlation coefficient (95%CI) of 2.2 (0.6-3.8) and 1.8 (0.5-3.2) respectively.
Conclusions:
The MMP-2 gene polymorphism rs243865 (-1306C>T) may have an association with measurable target organ damage in resistant hypertension.
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