Accepted for/Published in: JMIR Research Protocols
Date Submitted: Dec 28, 2024
Date Accepted: May 27, 2025
Comparative Evaluation of Effectiveness of Demineralized Freeze-Dried Bone Allografts (DFDBA) with Titanium Platelet Rich Fibrin (T-PRF) and Autologous Dentin Graft (ADG) with T-PRF in Alveolar Socket Preservation: A Protocol for Randomized Controlled Trial
ABSTRACT
Background:
Socket preservation is a pivotal procedure in modern dentistry, dedicated to the preservation of the alveolar ridge architecture after tooth extraction. The techniques vary from basic socket fillers such as blood clot preservation to more advanced techniques using barrier membranes and bone grafts such as autografts, allografts, xenografts, and synthetic materials. The aim of this study is to evaluate and compare the effectiveness of alveolar socket preservation with T-PRF (Titanium-Prepared Platelet-Rich Fibrin) and ADG (Autologous Dentin Graft) with T-PRF in socket preservation. This assessment will be carried out through comprehensive clinical, radiographic, and histomorphometric analysis.
Objective:
The objective is to determine the most efficient method for maintaining socket integrity after tooth extraction.The primary objective of this study is to histologically evaluate new bone formation and secondarily to evaluate the dimensional changes including ridge width and height at these healing points. (Clinical and biometric evaluation).
Methods:
A total of 16 patients who match the specified criteria will be randomly assigned to one of two groups:(1) Socket preservation using DFDBA in combination with TobjectPRF and (2) Socket preservation performed using ADG with T-PRF. Following four months all the clinical variables will be assessed, a CBCT radiograph will be used to examine volumetric bone status, and biopsies will be analyzed histomorphometrically obtained during implant placement. Linear phenotypic dimensional changes will be assessed as secondary outcomes.
Results:
The results obtained from this study will demonstrate if T-PRF along with ADG will lead to better radiographic bone fill and improved socket measurements compared to that of DFDBA with T-PRF.
Conclusions:
The results and patient-reported outcomes will be used to help choose the most effective type of therapy for socket preservation. Clinical Trial: The registration number for this trial is CTRI/2024/05/068192.
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