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Accepted for/Published in: JMIR Formative Research

Date Submitted: Dec 28, 2024
Date Accepted: May 12, 2025

The final, peer-reviewed published version of this preprint can be found here:

Determinant Factors of Stress in Caregivers of Patients With Schizophrenia: Cross-Sectional Study

Syarif I, Amqam H, Syamsuddin S, Hadju V, Russeng S, Amir Y

Determinant Factors of Stress in Caregivers of Patients With Schizophrenia: Cross-Sectional Study

JMIR Form Res 2025;9:e70648

DOI: 10.2196/70648

PMID: 40608481

PMCID: 12244270

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Exploring Stress Factors in Caregivers of Schizophrenia Patients: a PLS-SEM Model

  • Isymiarni Syarif; 
  • Hasnawati Amqam; 
  • Saidah Syamsuddin; 
  • Veni Hadju; 
  • Syamsiar Russeng; 
  • Yusran Amir

ABSTRACT

Background:

Individual caregivers of people with schizophrenia often face significant stress owing to the demands of caregiving and the complexity of managing mental health disorders

Objective:

This study aimed to explore the factors contributing to caregiver stress using Partial Least Squares Structural Equation Modeling (PLS-SEM)

Methods:

This study used a quantitative research design to identify the determinants of caregiver stress among individuals with schizophrenia. The sample for this study consisted of 110 caregivers of individuals with schizophrenia, who were selected through purposive sampling. Data were analyzed using the Partial Least Squares Structural Equation Modeling (PLS-SEM) approach

Results:

The results of this test show that the PLS model proposed in this study has a high predictive power. The validation of the PLS model met the high predictive power requirement. The overall model evaluation with R square, Q square, SRMR, and PLS Predict indicates that the PLS model proposed in this study is acceptable. Several environmental, situational, and individual characteristic factors have different influences on the stress levels of caregivers of patients with schizophrenia. From an environmental perspective, access to information does not significantly affect stress, while social support significantly reduces stress and stigma significantly increases stress. From a situational aspect, a high burden significantly increases stress, while non-compliance, coping, and knowledge show varying results, where only knowledge significantly reduces stress. individual characteristics, such as caregiving duration, employment, education, and age, do not have a significant influence on stress levels.

Conclusions:

These findings highlight the importance of social support, stigma reduction, and increased knowledge of efforts to manage caregivers' stress


 Citation

Please cite as:

Syarif I, Amqam H, Syamsuddin S, Hadju V, Russeng S, Amir Y

Determinant Factors of Stress in Caregivers of Patients With Schizophrenia: Cross-Sectional Study

JMIR Form Res 2025;9:e70648

DOI: 10.2196/70648

PMID: 40608481

PMCID: 12244270

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