Accepted for/Published in: JMIR Formative Research
Date Submitted: Nov 22, 2024
Open Peer Review Period: Dec 30, 2024 - Feb 24, 2025
Date Accepted: Apr 7, 2025
(closed for review but you can still tweet)
Prevalence of Multiple Chronic Conditions Among Adults in the All of Us Research Program: An Exploratory Analysis
ABSTRACT
Background:
Estimation of multiple chronic condition (MCC) prevalence throughout adulthood provides a critical reflection of MCC burden.
Objective:
We analyzed electronic health record codes for 58 conditions to estimate MCC prevalence for All of Us (AoU) Research Program adult participants (N=242,828).
Methods:
We conducted a cross-sectional analysis to estimate the number of participants with MCC using the version 7 Controlled Tier AoU Research Program data release. Data analysis was conducted using Python within the Researcher Workbench. Descriptive statistics included condition frequencies and participants’ age distributions aligned with age and diagnosis dates.
Results:
Approximately 76% of AoU participants were diagnosed with MCCs, with over 40% having 6 or more conditions and prevalence increasing with age; the most frequently occurring MCC combinations varied by age category (i.e., mental health conditions in early adulthood and physical health conditions in middle adulthood through advanced old age).
Conclusions:
We report notable prevalence of MCC throughout adulthood and variability in MCC condition combinations by age category in AoU participants. These findings highlight the need for targeted, innovative care modalities and population health initiatives to address MCC burden throughout adulthood. Clinical Trial: N/A
Citation
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Copyright
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