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Accepted for/Published in: JMIR Medical Education

Date Submitted: Nov 19, 2024
Date Accepted: Oct 7, 2025

The final, peer-reviewed published version of this preprint can be found here:

Comparison of Physician Assistant and Medical Students' Clinical Reasoning Processes Using an Online Patient Simulation Tool to Support Clinical Reasoning (eCREST): Mixed Methods Study

Thorpe A, Kassianos A, Plackett R, Krishnamurthy V, Kambouri M, Sheringham J

Comparison of Physician Assistant and Medical Students' Clinical Reasoning Processes Using an Online Patient Simulation Tool to Support Clinical Reasoning (eCREST): Mixed Methods Study

JMIR Med Educ 2025;11:e68981

DOI: 10.2196/68981

PMID: 41328485

PMCID: 12670056

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

An adaptation of eCREST, an online patient simulation tool to support clinical reasoning: A mixed-methods evaluation comparing clinical reasoning styles of physician associate and medical students

  • Alistair Thorpe; 
  • Angelos Kassianos; 
  • Ruth Plackett; 
  • Vinodh Krishnamurthy; 
  • Maria Kambouri; 
  • Jessica Sheringham

ABSTRACT

Background:

Clinical reasoning is increasingly recognised as an important skill in the diagnosis of serious conditions. eCREST (electronic Clinical Reasoning Educational Simulation Tool), a clinical reasoning learning resource was developed to support medical students to learn clinical reasoning. However, primary care teams now encompass a wider range of professional groups, such as Physician Associates [PAs] who also have a need to develop clinical reasoning during their training.

Objective:

We sought to evaluate the suitability of eCREST for physician associates, by comparing reasoning styles of PA and medical students using the tool.

Methods:

Between 2017 and 2021, PA students and medical students used eCREST to learn clinical reasoning skills in an experimental or learning context. Students undertook a simulated case of a patient presenting with chest pain. They could ask questions, order bedside tests, and select physical exams during the case, to help them form, reflect on and reconsider diagnostic ideas and management strategies while completing a case. Exploratory analysis was undertaken by comparing students’ data gathering, flexibility in diagnosis and diagnostic ideas between medical and PA students.

Results:

In total 159 medical students and 54 PA students completed the case. PAs were older (M=27±7 vs. M=24±4 years, p<.001) and more likely to be female (80% vs. 53%, p<.001). Medical and PA students were similar in the proportion of essential questions asked (M=70.13±22.24 vs. M=73.24±17.40, p=.326), physical examinations requested (M=54.7±18.6 vs. M=54.0±21.1, 50, p=.586), bedside tests selected (M=74.4±29.1 vs. M=83.3±28.8, p=.053), and number of times they changed their diagnoses (M=2.8±1.4 vs. M=2.8±1.5, p=.993). PA students initially included a greater proportion of relevant diagnoses (M=51.5±14.2 vs. M=43.4±14.4, p<.001), but both student groups improved during the case, particularly medical students (p=.046), and finished the case with similar proportions of relevant diagnoses (M=65.7±14.6 vs. M=62.9±15.5, p=.226).

Conclusions:

These results provide suggestive evidence that eCREST can serve the needs of both medical and PA students in developing clinical reasoning skills to support diagnosis in primary care.


 Citation

Please cite as:

Thorpe A, Kassianos A, Plackett R, Krishnamurthy V, Kambouri M, Sheringham J

Comparison of Physician Assistant and Medical Students' Clinical Reasoning Processes Using an Online Patient Simulation Tool to Support Clinical Reasoning (eCREST): Mixed Methods Study

JMIR Med Educ 2025;11:e68981

DOI: 10.2196/68981

PMID: 41328485

PMCID: 12670056

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