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Accepted for/Published in: JMIR Medical Informatics

Date Submitted: Nov 19, 2024
Date Accepted: May 23, 2025

The final, peer-reviewed published version of this preprint can be found here:

Evaluation of ChatGPT-4 as an Online Outpatient Assistant in Puerperal Mastitis Management: Content Analysis of an Observational Study

AY OF, Dolu F, Kupeli AH, Karademir E, Büyükavcı MH

Evaluation of ChatGPT-4 as an Online Outpatient Assistant in Puerperal Mastitis Management: Content Analysis of an Observational Study

JMIR Med Inform 2025;13:e68980

DOI: 10.2196/68980

PMID: 40705609

PMCID: 12288767

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Evaluation of ChatGPT Responses on Puerperal Mastitis: AI Response Quality and Safety An Observational Study on Mastitis

  • OĞUZHAN FATİH AY; 
  • Fatih Dolu; 
  • Aydın Hakan Kupeli; 
  • Enes Karademir; 
  • Muhammed Huseyin Büyükavcı

ABSTRACT

Background:

Puerperal mastitis, affecting up to 30% of breastfeeding women, is a common condition managed in general surgery outpatient clinics. The increasing integration of artificial intelligence (AI) into healthcare presents opportunities for enhancing decision-making processes.

Objective:

This study evaluates ChatGPT’s responses to frequently asked questions about puerperal mastitis, focusing on their quality, adherence to clinical guidelines, and patient safety.

Methods:

Fifteen questions were categorized into general information (n=2), symptoms and diagnosis (n=6), treatment (n=2), and prognosis (n=5). These questions, written in Turkish to reflect the target population, were input into ChatGPT 4.0. Responses were evaluated by five raters using criteria including sufficient length, understandability, accuracy, adherence to literature, and patient safety. DISCERN and Flesch-Kincaid readability scores were also calculated. Statistical analyses compared ratings across question categories and criteria.

Results:

ChatGPT’s responses were rated as “excellent” overall, with higher scores for treatment and prognosis-related questions. DISCERN scores showed significant differences between question categories (p=0.014), with treatment questions receiving the highest ratings. Flesch-Kincaid scores indicated readability at a university graduate level. While strong correlations were observed between adherence to literature and patient safety in certain questions, evaluator consistency varied, with significant differences in accuracy (p<0.001).

Conclusions:

ChatGPT demonstrated adequate capability in providing information on puerperal mastitis, particularly for treatment and prognosis. However, evaluator variability and the subjective nature of assessments highlight the need for further optimization of AI tools. Future research should emphasize iterative questioning and dynamic updates to AI knowledge bases to enhance reliability and accessibility


 Citation

Please cite as:

AY OF, Dolu F, Kupeli AH, Karademir E, Büyükavcı MH

Evaluation of ChatGPT-4 as an Online Outpatient Assistant in Puerperal Mastitis Management: Content Analysis of an Observational Study

JMIR Med Inform 2025;13:e68980

DOI: 10.2196/68980

PMID: 40705609

PMCID: 12288767

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