Accepted for/Published in: JMIR Formative Research
Date Submitted: Nov 12, 2024
Date Accepted: Apr 2, 2025
Probing the Relationship between Perioperative Complications in Patients with Valvular Heart Disease: Network Analysis based on Bayesian Network
ABSTRACT
Background:
Heart valve surgery is associated with a high risk of perioperative complications. However, current approaches for predicting perioperative complications are all based on preoperative or intraoperative factors, without taking into account the fact that perioperative complications are multifactorial, dynamic, heterogeneous, and interdependent.
Objective:
We aimed at constructing and quantifying the association network among multiple perioperative complications to elucidate the possible evolution trajectories.
Methods:
This study utilized the data from China Cardiac Surgery Registry (CCSR). Bayesian network was used to analyze the associations among 12 complications. Score-based hill-climbing algorithms were used to build the structure and the association between them was quantified using conditional probabilities.
Results:
We obtained the network of valve surgery complications. 13 nodes represented complications or death, and 34 arcs with arrows represented the directly dependent relationship between them. We identified clusters of complications that were logically related and not related, and quantified the associations. Meanwhile, the probability of death when multiple complications occurred was calculated.
Conclusions:
Our network facilitates the identification of associations among specific complications, which help to develop targeted measures to halt the cascade of complications in patients undergoing the valve surgery.
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Copyright
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